Angiogenin

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Angiogenin Informations sur la molécule

Molecule Name

Angiogenin

Alias de la molécule

ALS9,ANG,Angiogenin,angiogenin, ribonuclease, RNase A family, 5,EC 3.1.27,EC:3.1.27.-

Drug Development Progress

Nombre de médicaments cliniques0

Nombre de médicaments commercialisés0

Phase de R&D la plus avancéePreclinical

Alias de la cible

Ribonuclease 5，RNASE5，RAA1，Homo Sapiens Epididymis Luminal Protein 168，Angiogenin， Ribonuclease， RNase A Family， 5，Ribonuclease A Family Member 5，RNase 5，HEL168，Epididymis Luminal Protein 168

Contexte de la molécule

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo