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Axl

Axl

Axl Informations sur la molécule

Molecule Name
AXL receptor tyrosine kinase
Alias de la molécule
AXL,UFO
Drug Development Progress
Nombre de médicaments cliniques27
Nombre de médicaments commercialisés2
Phase de R&D la plus avancéeApproved
Alias de la cible
EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
Contexte de la molécule
AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

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Coopération sous licence

Nom du projetType de médicamentDomain thérapeutiqueIndicationPhaseZone de droits
AXL inhibitorSmall moleculeOncology/CancerSTK11_mut NSCLC,other cancersPhase IGlobal
Nom du projet
AXL inhibitor
Type de médicament
Small molecule
Domain thérapeutique
Oncology/Cancer
Indication
STK11_mut NSCLC,other cancers
Phase
Phase I
Zone de droits
Global