B7-H2

B7-H2 Informations sur la molécule

Nom anglais	ICOS ligand	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	Inducible T-Cell Co-Stimulator Ligand，B7-like protein Gl50，B7-H2，B7RP-1，B7-related protein 1，B7H2，GL50，B7RP1，CD275 Antigen，ICOSL，Inducible T-Cell Costimulator Ligand，B7h，B7 Homologue 2，KIAA0653，Inducible T Cell Costimulator Ligand，Transmembrane Protein B7-H2 ICOS Ligand，ICOS-L，LICOS，B7 homolog 2，CD275，ICOSLG
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	ICOS ligand
Alias de la cible	Inducible T-Cell Co-Stimulator Ligand，B7-like protein Gl50，B7-H2，B7RP-1，B7-related protein 1，B7H2，GL50，B7RP1，CD275 Antigen，ICOSL，Inducible T-Cell Costimulator Ligand，B7h，B7 Homologue 2，KIAA0653，Inducible T Cell Costimulator Ligand，Transmembrane Protein B7-H2 ICOS Ligand，ICOS-L，LICOS，B7 homolog 2，CD275，ICOSLG
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

B7-H2 Liste de produits

Attribut
Protein (7)
Bibliothèque de produits
En ligne (7)
Espèces
Human (2)Mouse (2)Cynomolgus (2)Rabbit (1)
Étiquette
His Tag (4)Fc Tag (2)His Tag & Avi Tag (1)
Marqueur
Unconjugated (6)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT B72-H5221	Human	HEK293	Human B7-H2 / ICOSLG Protein, His Tag (MALS verified)	Ajouter au panier
HOT B72-H5254	Human	HEK293	Human B7-H2 / ICOSLG Protein, Fc Tag	Ajouter au panier
B72-M5258	Mouse	HEK293	Mouse B7-H2 / ICOSLG Protein, Fc Tag	Ajouter au panier
B72-M52H7	Mouse	HEK293	Mouse B7-H2 / ICOSLG Protein, His Tag	Ajouter au panier
B72-C52Hb	Cynomolgus	HEK293	Cynomolgus B7-H2 / ICOSLG Protein, His Tag	Ajouter au panier
B72-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus B7-H2 / ICOSLG Protein, His,Avitag™ (MALS verified)	Ajouter au panier
B72-R52H3	Rabbit	HEK293	Rabbit B7-H2 / ICOSLG Protein, His Tag	Ajouter au panier

Quantité totale7

B7-H2Contexte de la molécule

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

B7-H2Alias de la molécule

ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Rozibafusp alfa	MEDI-0700; AMG-570	Phase 2 Clinical	Amgen Inc	Arthritis, Rheumatoid; Lupus Erythematosus, Systemic	Details

Avis sur les produits

1***22020-01-10
2Mettre un like
Human B7-H2 / ICOSLG Protein, Fc Tag
I purchased this Human B7H2 and only performed one SDS-PAGE. The purity is pretty good and similar to the one on their website.