Bcl-x

Bcl-x Informations sur la molécule

Nom anglais	Apoptosis regulator Bcl-X	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	8	Alias de la cible	Bcl-2-like protein 1，Bcl2-L-1，BCL2L，Apoptosis regulator Bcl-X，BCL2L1，BCL2 Like 1，Protein Phosphatase 1， Regulatory Subunit 52，BCLX，BCL-XL/S，PPP1R52，Bcl-X，bcl-X Protein，Bcl-XL，Bcl-XS
Phase de R&D la plus avancée	Approved

Nom anglais	Apoptosis regulator Bcl-X
Alias de la cible	Bcl-2-like protein 1，Bcl2-L-1，BCL2L，Apoptosis regulator Bcl-X，BCL2L1，BCL2 Like 1，Protein Phosphatase 1， Regulatory Subunit 52，BCLX，BCL-XL/S，PPP1R52，Bcl-X，bcl-X Protein，Bcl-XL，Bcl-XS
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	8
Phase de R&D la plus avancée	Approved

Bcl-x Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (2)
Étiquette
His Tag (1)GST Tag (1)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
BC1-H5120	Human	E. coli	Human Bcl-x / BCL2L1 Protein, His Tag				Ajouter au panier
BC1-H513a	Human	E. coli	Human Bcl-x / BCL2L1 Protein, GST Tag				Ajouter au panier

Quantité totale2

Bcl-xContexte de la molécule

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Bcl-xAlias de la molécule

BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL,S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Pelcitoclax	BM-1252; APG-1252; APG 1252 12A	Phase 2 Clinical	Jiangsu Ascentage Pharma Co Ltd	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fallopian Tube Neoplasms; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Non-Hodgkin; Neuroendocrine Tumors; Ovarian Neoplasms; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Small Cell Lung Carcinoma; Solid tumours	Details
LP-118	LP-118; NWP-0476; NWP-4-76	Phase 2 Clinical	Guangzhou Lupeng Pharmaceutical Co Ltd, Newave Pharmaceutical Inc	Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Prolymphocytic, T-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Richter's Syndrome; Solid tumours	Details
Foselutoclax	UBX-1325	Phase 2 Clinical	Ascentage Pharma Group International	Diabetic macular oedema; Macular Degeneration	Details
R-(-)-gossypol acetic acid	R-(-) BL-193; AT-101; NSC-726190	Phase 2 Clinical	Jiangsu Ascentage Pharma Co Ltd, University Of Michigan	Adrenocortical Carcinoma; Brain Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Esophageal Neoplasms; Glioblastoma; Gliosarcoma; Hormone-Resistant Prostate Neoplasms; Laryngeal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Lymphomatoid Granulomatosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Waldenstrom Macroglobulinemia	Details
Mirzotamab clezutoclax	ABBV-155	Phase 1 Clinical	Abbvie Inc	Solid tumours	Details
TQB-3142	TQB-3142	Phase 1 Clinical	Sino Biopharmaceutical Ltd	Neoplasms	Details
DT-2216	DT-2216	Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center, University Of Florida, UT Health San Antonio	Hematologic Neoplasms; Solid tumours	Details
ABBV-637	ABBV-637	Phase 1 Clinical	Abbvie Inc	Carcinoma, Non-Small-Cell Lung; Solid tumours	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Gossypol acetic acid/Potassium Chloride/Vitamin B1/Vitamin B6		Approved	Xi'An Beifang Medicine Co Ltd		Mainland China	Uterine Hemorrhage; Uterine Neoplasms; Endometriosis	Xi'An Beifang Medicine Co Ltd	1988-01-01	Endometriosis; Uterine Hemorrhage; Uterine Neoplasms	Details