C1q R1

C1q R1

C1q R1 Informations sur la molécule

Molecule Name
Complement component C1q receptor
Alias de la molécule
CD93,CDw93,C1QR1,MXRA4,C1qR,C1qR(P),C1qRP,ECSM3
Drug Development Progress
Nombre de médicaments cliniques0
Nombre de médicaments commercialisés0
Phase de R&D la plus avancéePreclinical
Alias de la cible
C1q/MBL/SPA receptor,C1qR,C1qRp,C1qR(p),CDw93,Complement component 1 q subcomponent receptor 1,Matrix-remodeling-associated protein 4
Contexte de la molécule
CD antigen CD93 is also known as Complement component C1q receptor (C1QR1). which belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin. CD93 contains one C-type lectin domain and five EGF-like domains. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). CD93 may mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and may play a role in intercellular adhesion.

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