CBLB

CBLB Informations sur la molécule

Nom anglais	E3 ubiquitin-protein ligase CBL-B	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3	Alias de la cible	Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	E3 ubiquitin-protein ligase CBL-B
Alias de la cible	Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Phase 2 Clinical

CBLB Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
CBB-H5148	Human	E. coli	Human CBLB / RNF56 Protein, His Tag				Ajouter au panier

Quantité totale1

CBLBContexte de la molécule

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

CBLBAlias de la molécule

CBL-B,CBLB,RNF56

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
HST-1011	HST-1011; HST1011	Phase 2 Clinical	HotSpot Therapeutics Inc	Neoplasms; Solid tumours	Details
APN-401	APN-401	Phase 1 Clinical	Apeiron Biologics	Brain metastases; Carcinoma, Renal Cell; Colorectal Neoplasms; Melanoma; Neoplasm Metastasis; Pancreatic Neoplasms; Solid tumours	Details
NX-1607	NX-1607	Phase 1 Clinical	Nurix Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mesothelioma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Richter's Syndrome; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms	Details