CD206

CD206 Informations sur la molécule

Nom anglais	Macrophage mannose receptor 1	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	2	Alias de la cible	C-type lectin domain family 13 member D，CLEC13D，Macrophage mannose receptor 1-like protein 1，hMR，Macrophage mannose receptor 1，C-type lectin domain family 13 member D-like，CLEC13DL，MRC1L1，MRC1，Mannose Receptor C-Type 1，Mannose Receptor， C Type 1-Like 1，Human Mannose Receptor，MMR，Mannose Receptor， C Type 1，CD206 Antigen，BA541I19.1，CD206
Phase de R&D la plus avancée	Approved

Nom anglais	Macrophage mannose receptor 1
Alias de la cible	C-type lectin domain family 13 member D，CLEC13D，Macrophage mannose receptor 1-like protein 1，hMR，Macrophage mannose receptor 1，C-type lectin domain family 13 member D-like，CLEC13DL，MRC1L1，MRC1，Mannose Receptor C-Type 1，Mannose Receptor， C Type 1-Like 1，Human Mannose Receptor，MMR，Mannose Receptor， C Type 1，CD206 Antigen，BA541I19.1，CD206
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	2
Phase de R&D la plus avancée	Approved

CD206 Liste de produits

Attribut
Protein (7)
Bibliothèque de produits
En ligne (7)
Espèces
Human (3)Mouse (2)Cynomolgus (2)
Étiquette
His Tag (4)His Tag & Avi Tag (3)
Marqueur
Unconjugated (3)Biotin-labeled (4)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT CD6-H52H9	Human	HEK293	Human CD206 / MMR Protein, His Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT CD6-H82E4	Human	HEK293	Biotinylated Human CD206 / MMR Protein, His,Avitag™	Ajouter au panier
HOT CD6-H82H6	Human	HEK293	Biotinylated Human CD206 / MMR Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)	Ajouter au panier
HOT CD6-M52H7	Mouse	HEK293	Mouse CD206 / MMR Protein, His Tag (HPLC verified)	Ajouter au panier
CD6-M82E8	Mouse	HEK293	Biotinylated Mouse CD206 / MMR Protein, His,Avitag™ (HPLC verified)	Ajouter au panier
CD6-C52H7	Cynomolgus	HEK293	Cynomolgus CD206 / MMR Protein, His Tag (MALS verified)	Ajouter au panier
CD6-C82E4	Cynomolgus	HEK293	Biotinylated Cynomolgus CD206 / MMR Protein, His,Avitag™ (MALS verified)	Ajouter au panier

Quantité totale7

CD206Contexte de la molécule

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

CD206Alias de la molécule

MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
68Ga-tilmanocept		Phase 3 Clinical	Navidea Biopharmaceuticals Inc	Atherosclerosis; Carcinoma, Endometrioid; Endometrial Neoplasms; Tuberculosis	Details
68GaNOTA-Anti-MMR-VHH2		Phase 2 Clinical	Universitair Ziekenhuis Brussel	Atherosclerosis; Carcinoma, Non-Small-Cell Lung; Carotid Stenosis; Hodgkin Disease; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoidosis	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Technetium Tc 99m tilmanocept	NEO3-09	Approved	University Of California	Lymphoseek Kit, Lymphoseek, Lymphoaim	United States	Solid tumours; Diagnostic agents; Breast Neoplasms; Melanoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms	Cardinal Health 414 Llc	2013-03-13	Anus Neoplasms; Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Diagnostic agents; Endometrial Neoplasms; Head and Neck Neoplasms; HIV Infections; Liver Neoplasms; Melanoma; Metabolic Dysfunction-Associated Steatotic Liver Disease; Rectal Neoplasms; Sarcoidosis; Sarcoma, Kaposi; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	Details