CD27

CD27 Informations sur la molécule

Nom anglais	CD27 antigen	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	4	Alias de la cible	CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	CD27 antigen
Alias de la cible	CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	4
Phase de R&D la plus avancée	Phase 2 Clinical

CD27 Liste de produits

Attribut
Protein (6)
Bibliothèque de produits
En ligne (6)
Espèces
Human (4)Cynomolgus / Rhesus macaque (1)Mouse (1)
Étiquette
Fc Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (3)His Tag (1)
Marqueur
Unconjugated (5)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT CD7-H522b	Human	HEK293	Human CD27 / TNFRSF7 Protein, His Tag (MALS verified)	Ajouter au panier
HOT CD7-H5254	Human	HEK293	Human CD27 / TNFRSF7 Protein, Fc Tag (MALS verified)	Ajouter au panier
HOT CD7-H5257	Human	HEK293	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT TN7-H82F6	Human	HEK293	Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™	Ajouter au panier
HOT CD7-M5252	Mouse	HEK293	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT CD7-C5259	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)	Ajouter au panier

Quantité totale6

CD27Contexte de la molécule

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27Alias de la molécule

CD27,TNFRSF7,S152,T14,Tp55

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Varlilumab	CDX-1127	Phase 2 Clinical	Celldex Therapeutics	Adenocarcinoma; Astrocytoma; Bile Duct Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Lymphoma; Cholangiocarcinoma; Gallbladder Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hormone-Resistant Prostate Neoplasms; Kidney Diseases; Kidney Neoplasms; Large intestine neoplasm; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Lung Neoplasms; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, Primary Effusion; Lymphoma, T-Cell; Lymphomatoid Granulomatosis; Melanoma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Plasmablastic Lymphoma; Prostatic Neoplasms; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Urologic Diseases; Urologic Neoplasms	Details
Boserolimab	MK-5890	Phase 1 Clinical	BioNovion Holding BV	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms	Details
LOR-S03	CDX-527	Phase 1 Clinical	Celldex Therapeutics	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Stomach Neoplasms	Details
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	Phase 1 Clinical	Aduro Biotech Inc	Neoplasms	Details