CD46

CD46 Informations sur la molécule

Nom anglais	Membrane cofactor protein	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5	Alias de la cible	TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Membrane cofactor protein
Alias de la cible	TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	Phase 2 Clinical

CD46 Liste de produits

Attribut
Protein (5)
Bibliothèque de produits
En ligne (5)
Espèces
Human (5)
Étiquette
His Tag (4)Fc Tag (1)
Marqueur
Unconjugated (2)FITC Labeled (1)APC Labeled (1)PE Labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
CD6-H5226	Human	HEK293	Human CD46 Protein, His Tag, low endotoxin (MALS verified)	Ajouter au panier
CD6-H5254	Human	HEK293	Human CD46 Protein, Fc Tag (MALS verified)	Ajouter au panier
CD6-HA224	Human	HEK293	APC-Labeled Human CD46 Protein, His Tag	Ajouter au panier
CD6-HF223	Human	HEK293	FITC-Labeled Human CD46 Protein, His Tag	Ajouter au panier
CD6-HP223	Human	HEK293	PE-Labeled Human CD46 Protein, His Tag	Ajouter au panier

Quantité totale5

Demande de produit

CD46Contexte de la molécule

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46Alias de la molécule

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Anti-CD46 antibody drug conjugate (Fortis Therapeutics)	FG-3246; FOR-46	Phase 2 Clinical	University Of California San Diego	Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	Details
Enadenotucirev	ColoAd-1; Oncolytic Ad11/Ad3	Phase 1 Clinical	Akamis Bio Ltd	Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms	Details
AugmAb	BRM-132	Phase 1 Clinical	Compliment Corp	Lymphoma, Non-Hodgkin; Neoplasms	Details
YS-5	YS-5	Phase 1 Clinical	Fortis Therapeutics Inc, United States Department Of Defense	Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	Details
FG-3180	89Zr-DFO-YS-5; 89Zr-DFO-YS5	Phase 1 Clinical	Fortis Therapeutics Inc	Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	Details