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CD47

CD47 Overview

English NameCluster of differentiation 47Approved Drugs0
Drugs in Clinical Trials51Target SynonymMER6，CD47，Leukocyte surface antigen CD47，CD47 Molecule，Antigenic Surface Determinant Protein OA3，CD47 Antigen (Rh-Related Antigen， Integrin-Associated Signal Transducer)，Antigen Identified By Monoclonal Antibody 1D8，Integrin Associated Protein，Rh-Related Antigen，CD47 Glycoprotein，IAP，Integrin-Associated Signal Transducer，Protein MER6，OA3，CD47 Antigen，Integrin-Associated Protein
Highest Development StagePhase 2 Clinical
English NameCluster of differentiation 47
Target SynonymMER6，CD47，Leukocyte surface antigen CD47，CD47 Molecule，Antigenic Surface Determinant Protein OA3，CD47 Antigen (Rh-Related Antigen， Integrin-Associated Signal Transducer)，Antigen Identified By Monoclonal Antibody 1D8，Integrin Associated Protein，Rh-Related Antigen，CD47 Glycoprotein，IAP，Integrin-Associated Signal Transducer，Protein MER6，OA3，CD47 Antigen，Integrin-Associated Protein
Approved Drugs0
Drugs in Clinical Trials51
Highest Development StagePhase 2 Clinical

CD47 Product List

  • Product Category

    Protein (21)Beads (3)Kits (2)

  • Product Status

    Launched (25)In Research (2)

  • Species

    Human (14)Mouse (5)Cynomolgus / Rhesus macaque (4)Rat (1)Rabbit (1)Canine (1)

  • Tag

    Fc Tag (5)His Tag (7)Fc Tag & Avi Tag (3)Mouse IgG Fc Tag (2)His Tag & Avi Tag (4)Mouse IgG Fc Tag & Avi Tag (1)- (5)

  • Conjugate

    Unconjugated (13)Biotin-labeled (7)FITC Labeled (1)- (4)PE Labeled (1)APC Labeled (1)

Total: 26
  • 1
  • 2
  • 3

CD47 Background

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

CD47 Synonyms

CD47,MER6,IAP,OA3

Project Cooperation

Product Reviews

  • A***r2023-01-31
    0People Like
    Human CD47 Protein, His Tag (MALS verified)
    A new ELISA binding was set up with this new recombinant protein. Among the various suppliers evaluated, the one from Acro Biosystem has been selected. Low doses are needed for coating in comparison to other providers. In addition, data quality was confirmed on repeatition runs. Finally, product delivery was quick and the interaction with our local business development manager is highly satisfaying.
  • R***e2022-09-10
    0People Like
    Human CD47 Protein, Fc Tag (MALS verified)
    Heard about ACRO from word of mouth from coworkers here at PPD and decided to browse the internet . My team purchased this product for some ELISA testing at the lab. We have been satisfied with the results so far. Great repeatability, sustainability, and specificity as compared to other vendors! It’s very creditable in my opinion. All and all ACRO definitely has some great quality products that are also more cost-effective compared to different vendors like MSD!
  • G***a2021-08-26
    0People Like
    Biotinylated Human CD47 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
    This human CD47-mIgG2aFC worked well in cell based binding assays as determined by flow cytometry. It bound to human SIRP alpha and SIRP gamma expressing cell lines (U87, THP-1, Jurkat T-ALL) as detected by an anti-mouse IgG2a secondary antibody. The binding to SIRP gamma expressing Jurkat cells was reduced when the cells were pre-incubated with SIRP gamma specific antibody clone LSB2.20, as expected.
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