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CD73

CD73 Overview

English Name	5'-nucleotidase	Approved Drugs	0
Drugs in Clinical Trials	36	Target Synonym	5' Nucleotidase (CD73)，5'-nucleotidase，5'-Nucleotidase， Ecto (CD73)，Ecto-5'-nucleotidase，NT5E，5'-Nucleotidase Ecto，Ecto-5-Nucleotidase，5-NT，Purine 5-Prime-Nucleotidase，5-Nucleotidase， Ecto (CD73)，5 Nucleotidase (CD73)，5-Nucleotidase Ecto，5-Nucleotidase，CD73 Antigen，EC 3.1.3.5，CALJA，E5NT，ENT，NT，EN，CD73，5'-NT，NT5，NTE，EC:3.1.3.5
Highest Development Stage	Phase 3 Clinical

English Name	5'-nucleotidase
Target Synonym	5' Nucleotidase (CD73)，5'-nucleotidase，5'-Nucleotidase， Ecto (CD73)，Ecto-5'-nucleotidase，NT5E，5'-Nucleotidase Ecto，Ecto-5-Nucleotidase，5-NT，Purine 5-Prime-Nucleotidase，5-Nucleotidase， Ecto (CD73)，5 Nucleotidase (CD73)，5-Nucleotidase Ecto，5-Nucleotidase，CD73 Antigen，EC 3.1.3.5，CALJA，E5NT，ENT，NT，EN，CD73，5'-NT，NT5，NTE，EC:3.1.3.5
Approved Drugs	0
Drugs in Clinical Trials	36
Highest Development Stage	Phase 3 Clinical

CD73 Product List

Product Category
Protein (8)Antibody (2)
Product Status
Launched (10)
Species
Human (3)Mouse (3)Cynomolgus (1)Canine (1)Rabbit (1)Rat (1)
Tag
His Tag (6)His Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (2)
Conjugate
Unconjugated (7)Biotin-labeled (1)PE Labeled (1)APC Labeled (1)

Cat. No.	Species	Host	Product Description
HOT CD3-H52H7	Human	HEK293	Human CD73 / NT5E Protein, His Tag (HPLC verified) (active enzyme)
HOT CD3-H82E3	Human	HEK293	Biotinylated Human CD73 / NT5E Protein, His,Avitag™
HOT CD3-M52H9	Mouse	HEK293	Mouse CD73 / NT5E Protein, His Tag (active enzyme)
CD3-H5252	Human	HEK293	Human CD73 Protein, Mouse IgG2a Fc Tag (active enzyme)
FABm024-01	Mouse	Hybridoma	PE-Labeled Monoclonal Anti-Human CD73 Antibody, Mouse IgG1 (5A10) (0.03% Proclin)
FABm024-02	Mouse	Hybridoma	APC-Labeled Monoclonal Anti-Human CD73 Antibody, Mouse IgG1 (5A10) (0.03% Proclin)
CD3-C52H5	Canine	HEK293	Canine CD73 / NT5E Protein, His Tag (MALS verified) (active enzyme)
CD3-C52H9	Cynomolgus	HEK293	Cynomolgus CD73 Protein, His Tag (active enzyme)
CD3-R52H3	Rabbit	HEK293	Rabbit CD73 / NT5E Protein, His Tag (active enzyme)
CD3-R52H5	Rat	HEK293	Rat CD73 Protein, His Tag (active enzyme)

Total: 10

CD73 Background

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

CD73 Synonyms

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Uliledlimab	TJD-5; TJ-004309; TJ-4309	Phase 3 Clinical	I-Mab Biopharma Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
Quemliclustat	AB-680	Phase 3 Clinical	Arcus Biosciences Inc	Adenocarcinoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Cholangiocarcinoma; Colorectal Neoplasms; Hormone-Resistant Prostate Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	Details
Oleclumab	MEDI-9447	Phase 3 Clinical	Medimmune Llc	Adenocarcinoma; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Colorectal Neoplasms; Fallopian Tube Neoplasms; Hemangiosarcoma; Liposarcoma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms	Details
Dalutrafusp alfa	GS-1423; AGEN-1423	Phase 2 Clinical	Agenus Inc	Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Liver Neoplasms; Pancreatic Neoplasms; Solid tumours	Details
BMS-986179	BMS-986179	Phase 2 Clinical	Bristol-Myers Squibb Company	Solid tumours	Details
Mupadolimab	CPX-006; COR-004 (Corvus Pharmaceuticals); CPI-006	Phase 2 Clinical	Corvus Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Endometrial Neoplasms; Head and Neck Neoplasms; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Pancreatic Neoplasms; Papillomavirus Infections; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
XW-LTH-03	XW-LTH-03	Phase 2 Clinical	Shanghai SinoBay Biotechnology Co Ltd	Stomach Neoplasms	Details
CD73/AXL.HypoSti.CAR-T cells therapy (Pla General Hospital)		Phase 2 Clinical	Pla General Hospital	Solid tumours	Details
Dresbuxelimab	AK-119	Phase 2 Clinical		Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Solid tumours	Details
GI-108	GI-108	Phase 2 Clinical	GI Innovation Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
S-095024	S-095024; S095024	Phase 2 Clinical	Institut De Recherches Internationales Servier, Regeneron Pharmaceuticals Inc, Servier Bio-Innovation LLC	Carcinoma, Non-Small-Cell Lung	Details
HB-0052	HB0052; HB-0052	Phase 2 Clinical	Shanghai Huaota Biopharmaceutical Co Ltd, Zhejiang Huahai Pharmaceutical Co Ltd	Pancreatic Neoplasms; Solid tumours	Details
HB-0045	HB-0045; HB0045	Phase 2 Clinical	HuaBo Biopharm Co Ltd, Shanghai Huaota Biopharmaceutical Co Ltd	Solid tumours	Details
JAB-BX102	JAB-BX102	Phase 2 Clinical	Jacobio Pharmaceuticals Co Ltd	Solid tumours	Details
PT-199	PT-199	Phase 2 Clinical	Phanes Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Solid tumours	Details
LY-3475070	LY-3475070	Phase 1 Clinical	Eli Lilly And Company	Neoplasms	Details
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb)		Phase 1 Clinical	Bristol-Myers Squibb Company	Neoplasms	Details
AP-601	AP-601	Phase 1 Clinical	AP Biosciences Inc	Neoplasms; Solid tumours	Details
68Ga-dPNE	68Ga-dPNE	Phase 1 Clinical	First Affiliated Hospital Of Fujian Medical University	Neoplasms	Details
AK-137	AK137; AK-137	Phase 1 Clinical		Neoplasms	Details
68GA-DOTA-dPNE	68GA-DOTA-dPNE	Phase 1 Clinical	Peking Union Medical College Hospital	Breast Neoplasms	Details
LNF-2008	LNF-2008; LNF2008	Phase 1 Clinical	Shandong New Time Pharmaceutical Co Ltd	Solid tumours	Details
HB-0046	HB0046; HB-0046	Phase 1 Clinical	HuaBo Biopharm Co Ltd, Shanghai Huaota Biopharmaceutical Co Ltd	Solid tumours	Details
SYS-6011	SYS6011; SYS-6011	Phase 1 Clinical	Jushi Biopharmaceutical Co Ltd	Solid tumours	Details
BPI-472372	BPI-472372	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Solid tumours	Details
BB-1709	BB-1709	Phase 1 Clinical	Bliss Biopharmaceutical (Hangzhou) Co Ltd	Solid tumours	Details
PM-1015	PM1015; PM-1015	Phase 1 Clinical		Solid tumours	Details
AK-131	AK-131	Phase 1 Clinical		Neoplasms; Solid tumours	Details
IBI-325	IBI-325	Phase 1 Clinical		Solid tumours	Details
BR-101	BR101; BR-101	Phase 1 Clinical	Zhejiang BioRay Biopharmaceuticals Co Ltd	Solid tumours	Details
CB-708	ATG-037; ATN-037; CB-708; CB708	Phase 1 Clinical	Calithera Biosciences Inc	Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasms; Solid tumours	Details
HLX-23	HLX-23	Phase 1 Clinical		Lymphoma; Solid tumours	Details
ORIC533	ORIC-533	Phase 1 Clinical	Oric Pharmaceuticals Inc	Multiple Myeloma; Neoplasm Metastasis	Details
IPH-5301	IPH-5301	Phase 1 Clinical	Innate Pharma	Breast Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Lung Neoplasms; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms	Details
HBM-1007	HBM1007; R 1007; HBM 1007; HBM-1007	Phase 1 Clinical	Harbour Biomed	Neoplasms; Solid tumours	Details
ABSK-051	ABSK051	Phase 1 Clinical	ABbisko Therapeutics Co Ltd	Neoplasms; Solid tumours	Details

Product Reviews

H***g2021-11-29
0People Like
Mouse CD73 / NT5E Protein, His Tag (active enzyme)
It was used in research of investgational new drugs. Specifically, I have used this product in my Epitope binning experiments (using Octet) and I am truely satisfied with the results. With this experiment and your product, we have found a approximate epitope binding site. Thanks for your highly qualified product.