CD74

CD74 Informations sur la molécule

Nom anglais	HLA-DR antigens-associated invariant chain	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5	Alias de la cible	CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	HLA-DR antigens-associated invariant chain
Alias de la cible	CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	Phase 1 Clinical

CD74 Liste de produits

Attribut
Protein (3)
Bibliothèque de produits
En ligne (3)
Espèces
Human (3)
Étiquette
His Tag (1)Fc Tag (1)Llama IgG Fc Tag (1)
Marqueur
Unconjugated (3)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
CD4-H524c	Human	HEK293	Human CD74 / DHLAG Protein, His Tag, low endotoxin (HPLC verified)	Ajouter au panier
CD4-H5256	Human	HEK293	Human CD74 / DHLAG Protein, Fc Tag (MALS verified)	Ajouter au panier
CD4-H5258	Human	HEK293	Human CD74 / DHLAG Protein, Llama IgG2b Fc Tag, low endotoxin	Ajouter au panier

Quantité totale3

Demande de produit

CD74Contexte de la molécule

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74Alias de la molécule

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Influenza A M1 vaccine (Pascal Biosciences)		Phase 1 Clinical	Pascal Biosciences	Influenza A virus infections	Details
adenovector based vaccine (Pascal Biosciences/University of British Columbia)		Phase 1 Clinical	Nevis Brands Inc	Influenza A virus infections	Details
90Y-2IT-BAD-Lym-1	90Y-2IT-BAD-Lym-1	Phase 1 Clinical	National Cancer Institute	Lymphoma, Non-Hodgkin	Details
Bezetabart debotansine	STRO-001; SP7675; SP-7675; BN-301	Phase 1 Clinical	Sutro Biopharma Inc	Hematologic Neoplasms; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma	Details
TROP-2-targeted anti-CD74 siRNA (Immunomedics)			Immunomedics Inc	Solid tumours	Details