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COMP

COMP Overview

English Name	Sodium channel protein type VIII alpha subunit	Approved Drugs	1
Drugs in Clinical Trials	4	Target Synonym	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
Highest Development Stage	Approved

English Name	Sodium channel protein type VIII alpha subunit
Target Synonym	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
Approved Drugs	1
Drugs in Clinical Trials	4
Highest Development Stage	Approved

COMP Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
COP-H5220	Human	HEK293	Human COMP / TSP5 Protein, His Tag

Total: 1

COMP Background

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

COMP Synonyms

COMP,TSP5,EDM1,EPD1,MED,PSACH,THBS5

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
PRAX-562	PRAX-562	Phase 3 Clinical	Praxis Precision Medicines	Brain Diseases; Epilepsy	Details
XEN-901	NBI-921352; XEN-901	Phase 2 Clinical	Xenon Pharma	Epilepsies, Partial; Brain Diseases; Epilepsy	Details
PRAX-330	GS-458967; GS-967; PRAX-330	Phase 1 Clinical	Praxis Precision Medicines Inc	Epilepsy	Details
NBI-355	NBI-355	Phase 1 Clinical	Neurocrine Biosciences Inc	Epilepsy	Details