COMP

COMP Informations sur la molécule

Nom anglais	Sodium channel protein type VIII alpha subunit	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	4	Alias de la cible	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
Phase de R&D la plus avancée	Approved

Nom anglais	Sodium channel protein type VIII alpha subunit
Alias de la cible	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	4
Phase de R&D la plus avancée	Approved

COMP Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
COP-H5220	Human	HEK293	Human COMP / TSP5 Protein, His Tag				Ajouter au panier

Quantité totale1

COMPContexte de la molécule

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

COMPAlias de la molécule

COMP,TSP5,EDM1,EPD1,MED,PSACH,THBS5

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
PRAX-562	PRAX-562	Phase 3 Clinical	Praxis Precision Medicines	Brain Diseases; Epilepsy	Details
XEN-901	NBI-921352; XEN-901	Phase 2 Clinical	Xenon Pharma	Epilepsies, Partial; Brain Diseases; Epilepsy	Details
PRAX-330	GS-458967; GS-967; PRAX-330	Phase 1 Clinical	Praxis Precision Medicines Inc	Epilepsy	Details
NBI-355	NBI-355	Phase 1 Clinical	Neurocrine Biosciences Inc	Epilepsy	Details