Complement Factor D

Complement Factor D Informations sur la molécule

Nom anglais	Complement factor D	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	5	Alias de la cible	EC 3.4.21，EC 3.4.21');，C3 Convertase Activator，ADIPSIN，D Component Of Complement (Adipsin)，PFD，Complement Factor D Preproprotein，Complement Factor D (Adipsin)，EC 3.4.21.46，ADN，CFD，Properdin factor D，DF，Complement factor D，EC:3.4.21.46
Phase de R&D la plus avancée	Approved

Nom anglais	Complement factor D
Alias de la cible	EC 3.4.21，EC 3.4.21');，C3 Convertase Activator，ADIPSIN，D Component Of Complement (Adipsin)，PFD，Complement Factor D Preproprotein，Complement Factor D (Adipsin)，EC 3.4.21.46，ADN，CFD，Properdin factor D，DF，Complement factor D，EC:3.4.21.46
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	Approved

Complement Factor D Liste de produits

Attribut
Protein (3)
Bibliothèque de produits
En ligne (3)
Espèces
Human (2)Cynomolgus / Rhesus macaque (1)
Étiquette
His Tag (2)Fc Tag (1)
Marqueur
Unconjugated (3)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT CFD-H5256	Human	HEK293	Human Complement Factor D / CFD Protein, Fc Tag	Ajouter au panier
HOT CFD-H52H8	Human	HEK293	Human Complement Factor D / CFD Protein, His Tag (active enzyme)	Ajouter au panier
CFD-R52H3	Cynomolgus / Rhesus macaque	HEK293	Rhesus macaque / Cynomolgus Complement Factor D / CFD Protein, His Tag (active enzyme)	Ajouter au panier

Quantité totale3

Complement Factor DContexte de la molécule

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Complement Factor DAlias de la molécule

CFD,Adipsin,PFD,DF,Complement factor D

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Vemircopan	ACH-0145228; ACH-5228; ALXN-2050	Phase 1 Clinical	Achillion Pharmaceuticals Inc	Glomerulonephritis, IGA; Hemoglobinuria, Paroxysmal; Hepatic Insufficiency; Lupus Nephritis; Myasthenia Gravis; Renal Insufficiency	Details
ACH-5548	ACH-5548; ACH-0145548	Phase 1 Clinical	Achillion Pharmaceuticals Inc	Autoimmune Diseases	Details
BCX-9930	BCX-9930	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	C3 glomerulopathy; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Hemoglobinuria, Paroxysmal	Details
BCX-10013	BCX-10013	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	Hemoglobinuria, Paroxysmal	Details
Zoracopan	ALXN-2080	Phase 1 Clinical	Alexion Pharmaceuticals Inc		Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Danicopan	ACH-4471; ACH-0144471; ACH-CFDIS; ALXN-2040	Approved	Achillion Pharmaceuticals Inc	VOYDEYA, Voydeya	Japan	Hemoglobinuria, Paroxysmal	Alexion Pharmaceuticals Inc	2024-01-18	C3 glomerulopathy; Coronavirus Disease 2019 (COVID-19); Geographic Atrophy; Glomerulonephritis, Membranoproliferative; Hemoglobinuria, Paroxysmal; Hemolysis; Hepatic Insufficiency	Details