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CX3CL1

CX3CL1 Overview

English Name	C-X3-C motif chemokine ligand 1	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Small Inducible Cytokine Subfamily D (Cys-X3-Cys)， Member 1 (Fractalkine， Neurotactin)，Small Inducible Cytokine Subfamily D (Cys-X3-Cys)， Member-1，CX3CL1，Small-inducible cytokine D1，FKN，Fractalkine，A-152E5.2，C-X3-C Motif Chemokine Ligand 1，Chemokine (C-X3-C Motif) Ligand 1，CX3C Membrane-Anchored Chemokine，C-X3-C Motif Chemokine 1，Neurotactin，SCYD1，NTT，C3Xkine，ABCD-3，CXC3C，CXC3，NTN，Chemokine CX3CL1
Highest Development Stage	Phase 2 Clinical

English Name	C-X3-C motif chemokine ligand 1
Target Synonym	Small Inducible Cytokine Subfamily D (Cys-X3-Cys)， Member 1 (Fractalkine， Neurotactin)，Small Inducible Cytokine Subfamily D (Cys-X3-Cys)， Member-1，CX3CL1，Small-inducible cytokine D1，FKN，Fractalkine，A-152E5.2，C-X3-C Motif Chemokine Ligand 1，Chemokine (C-X3-C Motif) Ligand 1，CX3C Membrane-Anchored Chemokine，C-X3-C Motif Chemokine 1，Neurotactin，SCYD1，NTT，C3Xkine，ABCD-3，CXC3C，CXC3，NTN，Chemokine CX3CL1
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

CX3CL1 Product List

Product Category
Protein (4)
Product Status
Launched (4)
Species
Human (3)Cynomolgus (1)
Tag
His Tag (3)His Tag & Avi Tag (1)
Conjugate
Biotin-labeled (2)Unconjugated (2)

Cat. No.	Species	Host	Product Description
HOT CX1-H8221	Human	HEK293	Biotinylated Human CX3CL1 Protein, His Tag, ultra sensitivity (primary amine labeling)
CX1-H5221	Human	HEK293	Human CX3CL1 / Fractalkine Protein, His Tag
CX1-H82E6	Human	HEK293	Biotinylated Human CX3CL1 Protein, His,Avitag™
CX1-C5222	Cynomolgus	HEK293	Cynomolgus CX3CL1 / Fractalkine Protein, His Tag (MALS verified)

Total: 4

CX3CL1 Background

Fractalkine is also known as C-X3-C motif chemokine 1 (CX3CL1) and neurotactin. Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is found commonly throughout the brain, particularly in neural cells, and its receptor is known to be present on microglial cells. It has also been found to be essential for microglial cell migration. CX3CL1 is also up-regulated in the hippocampus during a brief temporal window following spatial learning, the purpose of which may be to regulate glutamate-mediated neurotransmission tone. This indicates a possible role for the chemokine in the protective plasticity process of synaptic scaling.