Dkk-3

Dkk-3 Informations sur la molécule

Nom anglais	Dickkopf-related protein 3	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Dickkopf-related protein 3
Alias de la cible	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

Dkk-3 Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (1)Mouse (1)
Étiquette
His Tag (2)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
DK3-H5220	Human	HEK293	Human Dkk-3 (R335G) Protein, His Tag				Ajouter au panier
DK3-M5226	Mouse	HEK293	Mouse Dkk-3 Protein, His Tag				Ajouter au panier

Quantité totale2

Dkk-3Contexte de la molécule

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.