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E-Cadherin

E-Cadherin Overview

English Name	Cadherin-1	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	CAM 120/80，Epithelial cadherin，Ecad，Uvomorulin，CDHE，UVO
Highest Development Stage	Preclinical

English Name	Cadherin-1
Target Synonym	CAM 120/80，Epithelial cadherin，Ecad，Uvomorulin，CDHE，UVO
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

E-Cadherin Product List

Product Category
Protein (2)Antibody (1)
Product Status
Launched (3)
Species
Human (2)Mouse (1)
Tag
Fc Tag (2)- (1)
Conjugate
Unconjugated (3)

Cat. No.	Species	Host	Product Description
ECD-H5250	Human	HEK293	Human E-Cadherin / Cadherin-1 Protein, Fc Tag, premium grade
ECD-H5256	Human	HEK293	Human E-Cadherin / Cadherin-1 (155-709) Protein, Fc Tag (MALS verified)
HGS-S590	Mouse	-	Recombinant Monoclonal Anti-E-Cadherin Antibody, Mouse (3F7)

Total: 3

E-Cadherin Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).