EDNRB

EDNRB Informations sur la molécule

Nom anglais	Endothelin receptor type B	Nombre de médicaments commercialisés	5
Nombre de médicaments cliniques	5	Alias de la cible	Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B
Phase de R&D la plus avancée	Approved

Nom anglais	Endothelin receptor type B
Alias de la cible	Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B
Nombre de médicaments commercialisés	5
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	Approved

EDNRB Liste de produits

Attribut
Protein (4)
Bibliothèque de produits
En ligne (4)
Espèces
Human (4)
Étiquette
- (2)GFP Tag (1)His Tag & Flag Tag (1)
Marqueur
Unconjugated (3)GFP Fusion (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
EDB-H52D3	Human	HEK293	Human EDNRB Protein, Flag,His Tag (Detergent)	Ajouter au panier
EDB-H52D4	Human	E. coli	Human EDNRB Full Length Protein, His,Flag Tag (Detergent)	Ajouter au panier
EDB-H52P7	Human	HEK293	Human EDNRB Full Length Protein (VLP)	Ajouter au panier
EDB-HF2G4	Human	HEK293	Fluorescent Human EDNRB Full Length Protein (VLP)	Ajouter au panier

Quantité totale4

EDNRBContexte de la molécule

Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.

EDNRBAlias de la molécule

EDNRB,endothelin receptor type B,ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
VRP-1620	VRP-1620	Phase 3 Clinical	University Of Illinois	Breast Neoplasms	Details
Vodudeutentan	ENB-003; ENB-006	Phase 2 Clinical	Enb Therapeutics Inc	Melanoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours	Details
BQ-788	BQ-788	Phase 1 Clinical	Merck Serono	Cardiovascular Diseases; Hypertension; Melanoma	Details
GLX-002	GLX-002; GLX002	Phase 1 Clinical	Yabao Pharmaceutical Co Ltd Beijing	Pulmonary Arterial Hypertension	Details
Bosentan Orally Disintegrating Tablets(Beijing Sunho Pharma)		Phase 1 Clinical	Beijing Sunho Pharmaceutical Co Ltd	Pulmonary Arterial Hypertension	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Sovateltide	IRL-1620; PMZ-1620; SPI-1620	Approved	University Of Illinois At Chicago	Tyvalzi	India	Stroke	Pharmazz Inc	2023-05-31	Alzheimer Disease; Asphyxia Neonatorum; Biliary Tract Neoplasms; Brain Diseases; Brain Ischemia; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cerebral Infarction; Dementia; Ischemic Stroke; Spinal Cord Injuries; Stroke	Details
Macitentan/Tadalafil		Approved	Actelion Pharmaceuticals Ltd	OPSYNVI, Yuvanci	United States	Pulmonary Arterial Hypertension	Actelion Pharmaceuticals Us Inc	2024-03-22	Phenylketonurias; Pulmonary Arterial Hypertension	Details
Bosentan Hydrate	ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039	Approved	F. Hoffmann-La Roche Ltd	Stayveer, 全可利, Tracleer	United States	Pulmonary Arterial Hypertension	Actelion Pharmaceuticals Ltd	2001-11-20	Anemia, Sickle Cell; Chronic thromboembolic pulmonary hypertension; Coronary Vasospasm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Giant Cell Arteritis; Glaucoma; Heart Defects, Congenital; Heart Septal Defects, Atrial; Hepatopulmonary Syndrome; Hypertension; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung Diseases, Interstitial; Persistent Fetal Circulation Syndrome; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic; Sleep Apnea Syndromes; Takayasu Arteritis; Ulcer; Vasculitis	Details
Macitentan	ACT-064992; Actelion-1; JNJ-67896062	Approved	Actelion Pharmaceuticals Ltd	Zependo, Opsumit, 傲朴舒	United States	Pulmonary Arterial Hypertension	Actelion Pharmaceuticals Us Inc	2013-10-18	Anemia, Sickle Cell; Angina Pectoris; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Eisenmenger Complex; Glioblastoma; Heart Defects, Congenital; Heart Failure; Heart Failure, Diastolic; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Pulmonary Arterial Hypertension; Pulmonary Embolism; Scleroderma, Systemic; Scleroderma-associated interstitial lung diseases; Thromboembolism; Ulcer	Details
Aprocitentan	ACT-132577; AC-080; JNJ-2820	Approved	Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd	TRYVIO, JERAYGO	United States	Hypertension	Idorsia Pharmaceuticals Ltd	2024-03-19	Essential Hypertension; Hepatic Insufficiency; Hypertension; Renal Insufficiency, Chronic	Details