Endoglin

Endoglin Informations sur la molécule

Nom anglais	Endoglin	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2	Alias de la cible	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Endoglin
Alias de la cible	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2
Phase de R&D la plus avancée	Phase 2 Clinical

Endoglin Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
ENN-H52H9	Human	HEK293	Human Endoglin / CD105 Protein, His Tag				Ajouter au panier

Quantité totale1

EndoglinContexte de la molécule

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

EndoglinAlias de la molécule

Endoglin,CD105,ENG,END

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Carotuximab	DE-122; TRC-105; NSC#754227; Chimeric Antibody TRC-105; ENV-105	Phase 2 Clinical	Roswell Park Cancer Institute	Adenoma, Liver Cell; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Choriocarcinoma; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Glioblastoma; Glioma; Gliosarcoma; Hemangiosarcoma; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macular Degeneration; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Trophoblastic Neoplasms; Trophoblastic Tumor, Placental Site; Ureteral Neoplasms	Details
STEMVAC	EP-101	Phase 2 Clinical	Epithany	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; HR-positive breast cancer; Lung Neoplasms; Triple Negative Breast Neoplasms	Details