EphA4

EphA4 Informations sur la molécule

Nom anglais	Erythropoietin-producing hepatocellular receptor A4	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3	Alias de la cible	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	Erythropoietin-producing hepatocellular receptor A4
Alias de la cible	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Phase 1 Clinical

EphA4 Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
EP4-H52H8	Human	HEK293	Human EphA4 Protein, His Tag				Ajouter au panier

Quantité totale1

EphA4Contexte de la molécule

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4Alias de la molécule

EphA4,HEK8,SEK,TYRO1,EK8

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
ORT-247	ORT247; ORT-247	Phase 1 Clinical	Orthogonal Neuroscience Inc	Amyotrophic Lateral Sclerosis	Details
mEphA4-Fc	mEphA4-Fc	Phase 1 Clinical	Queensland Brain Institute	Amyotrophic Lateral Sclerosis; Nerve Degeneration; Nervous System Diseases	Details
E2025	E-2025; E2025	Phase 1 Clinical	Eisai Inc	Alzheimer Disease	Details