Select Language

Fc gamma RIIB/C / CD32b/c

Fc gamma RIIB/C / CD32b/c Overview

English Name	Low affinity immunoglobulin gamma Fc region receptor II-b	Approved Drugs	0
Drugs in Clinical Trials	5	Target Synonym	IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)，FcRII-C，FCGR2C，Fc-Gamma-RIIc
Highest Development Stage	Phase 3 Clinical

English Name	Low affinity immunoglobulin gamma Fc region receptor II-b
Target Synonym	IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)，FcRII-C，FCGR2C，Fc-Gamma-RIIc
Approved Drugs	0
Drugs in Clinical Trials	5
Highest Development Stage	Phase 3 Clinical

Fc gamma RIIB/C / CD32b/c Product List

Product Category
Protein (5)
Product Status
Launched (5)
Species
Human (5)
Tag
His Tag (1)His Tag & Avi Tag (1)HSA Tag & His Tag (1)His Tag & SUMO Tag (1)Strep Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT CDB-H5228	Human	HEK293	Human Fc gamma RIIB/C (CD32b/c) Protein, His Tag, low endotoxin (SPR & MALS verified)
HOT CDB-H5284	Human	HEK293	Human Fc gamma RIIB/C (CD32b/c) Protein, Strep Tag (MALS & SPR verified)
HOT CDB-H5298	Human	HEK293	Human Fc gamma RIIB/C (CD32b/c) Protein, SUMO,His Tag (MALS & BLI verified)
HOT CDB-H82E0	Human	HEK293	Biotinylated Human Fc gamma RIIB/C (CD32b/c) Protein, Avitag™,His Tag (SPR & MALS verified)
CDB-H52S9	Human	HEK293	Human Fc gamma RIIB/C (CD32b/c) Protein, HSA,His Tag (MALS & BLI verified)

Total: 5

Fc gamma RIIB/C / CD32b/c Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Fc gamma RIIB/C / CD32b/c Synonyms

FCGR2B,C,CD32b,c,FcRII-b,c,Fc-gamma RII-b,c,Fc-gamma-RIIb,c,CD32,FCG2,IGFR2,CDw32

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Obexelimab	XmAb-5871; AMG-729	Phase 3 Clinical	Xencor Inc	Anemia, Hemolytic, Autoimmune; Immunoglobulin G4-Related Disease; Lupus Erythematosus, Systemic; Multiple Sclerosis	Details
BI-1206	6G-11; BI-1206	Phase 2 Clinical	Bioinvent International Ab	Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Solid tumours; Waldenstrom Macroglobulinemia	Details
BI-1607	BI-1607	Phase 2 Clinical	Bioinvent International Ab	Adenocarcinoma; Breast Neoplasms; Esophageal Neoplasms; Melanoma; Metastatic breast cancer; Skin Melanoma; Solid tumours; Stomach Neoplasms; Uveal melanoma	Details
NVG-2089	NVG-2089	Phase 2 Clinical	Nuvig Therapeutics Inc	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic	Details
S-4321	S-4321	Phase 1 Clinical	Seismic Therapeutics Inc	Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Dermatitis, Atopic; Immune System Diseases; Lupus Erythematosus, Cutaneous; Psoriasis	Details