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FcRn (FCGRT & B2M)
FcRn (FCGRT & B2M) Informations sur la molécule
| Nom anglais | IgG receptor FcRn large subunit p51 | Nombre de médicaments commercialisés | 4 |
| Nombre de médicaments cliniques | 4 | Alias de la cible | Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor |
| Phase de R&D la plus avancée | Approved | ||
| Nom anglais | IgG receptor FcRn large subunit p51 |
| Alias de la cible | Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor |
| Nombre de médicaments commercialisés | 4 |
| Nombre de médicaments cliniques | 4 |
| Phase de R&D la plus avancée | Approved |
FcRn (FCGRT & B2M) Liste de produits
- Attribut
Protein (22)Cell (2)Kits (1)
- Bibliothèque de produits
En ligne (25)
- Espèces
Human (9)Cynomolgus / Rhesus macaque (4)Rat (2)Mouse (4)Porcine (1)Feline (1)Rabbit (2)Canine (2)
- Étiquette
His Tag & Strep Tag (6)His Tag & Strep Tag & Avi Tag (3)His Tag & Avi Tag & Strep Tag (1)His Tag & Avi Tag (6)His Tag (5)- (3)Strep Tag (1)
- Marqueur
Unconjugated (11)Biotin-labeled (11)- (3)
Ajouter au panier
Quantité totale25
- 1
- 2
- 3
FcRn (FCGRT & B2M)Contexte de la molécule
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
FcRn (FCGRT & B2M)Alias de la molécule
FcRn,FCGRT & B2M
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| IMVT-1402 | IMVT-1402; HL-161 ANS | Phase 3 Clinical | HanAll Biopharma Co Ltd | Arthritis, Rheumatoid; Autoimmune Diseases; Graves Disease; Lupus Erythematosus, Cutaneous; Myasthenia Gravis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome | Details |
| STSA-1301 | STSA-1301; STSA1301 | Phase 2 Clinical | Staidson(Beijing) Biopharmaceuticals Co Ltd | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | Details |
| ARGX-124 | ARGX124; ARGX-124 | Phase 1 Clinical | Argenx Se | Immune System Diseases | Details |
| ARGX-213 | ARGX-213 | Phase 1 Clinical | Argenx Se | Autoimmune Diseases | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Efgartigimod alfa | EFG PH20 SC; PH20 SC; ARGX-113-2308; ARGX-113; EFG PH20 | Approved | Argenx Se | VYVDURA, VYVGART HYTRULO, 卫伟迦, VYVGART | United States | Myasthenia Gravis | Argenx BV | 2021-12-17 | Epidermolysis Bullosa; Epidermolysis Bullosa Acquisita; Epidermolysis Bullosa Dystrophica; Eye Diseases; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Guillain-Barre Syndrome; Immunoglobulin G4-Related Disease; Lupus Nephritis; Muscular Diseases; Myasthenia Gravis; Myositis; Nephrosis; Nephrotic Syndrome; Optic Neuritis; Pemphigoid, Bullous; Pemphigus; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Postural Orthostatic Tachycardia Syndrome; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Rejection of organ transplantation; Scleroderma, Systemic; Sjogren's Syndrome; Stiff-Person Syndrome; Tachycardia; Thrombocytopenia | Details |
| Nipocalimab | M-281; JNJ-80202135 | Approved | Momenta Pharmaceuticals Inc | IMAAVY | United States | Myasthenia Gravis | Janssen Biotech Inc | 2025-04-29 | Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Hemolysis; Lupus Erythematosus, Systemic; Lupus Nephritis; Myasthenia Gravis; Myositis; Pemphigoid, Bullous; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Thrombocytopenia, Neonatal Alloimmune | Details |
| Rozanolixizumab | UCB-7665 | Approved | Ucb Sa | RYSTIGGO, 优迪革 | United States | Myasthenia Gravis | Ucb Inc | 2023-06-27 | Encephalitis; Fibromyalgia; Myasthenia Gravis; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic | Details |
| Efgartigimod alfa/Hyaluronidase | Approved | Argenx BV | VYVDURA, VYVGART HYTRULO | United States | Myasthenia Gravis | Argenx BV | 2023-06-20 | Anti-synthetase Syndrome; Dermatomyositis; Muscular Diseases; Myasthenia Gravis; Myositis; Polymyositis; Polyradiculoneuropathy; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating | Details |
Avis sur les produits
I***a2026-04-14
0Mettre un likeI purchased rat fcrn from acrobio systems. It was a 25ug powder and I dissolved in my pbs buffer and aliquoted and kept in -20C. I used that fcrn to check the binding kinetics with human igg and assay was successful.FcRn was in high quality- N***i2024-12-24 0Mettre un likeI recently used the Biotinylated Rabbit FcRn on the Biacore 8K+ and was highly impressed with its performance. The product worked perfectly as described, delivering reliable and consistent results. It also arrived within the expected time frame, which I greatly appreciated. Overall, I am very satisfied with the quality and service, and I would highly recommend this product to others
- C***n2023-05-03 1Mettre un likeI used Acro's FcRn for development of novel assays. The proteins within just a few days of placing the order. The proteins were also high quality, stable, and did not result in any background in any of the assays that were developed, even after using them for months. These produced great data and we have continued to repurchase them since. I would highly recommend this product.
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- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments commercialisés
- Avis sur les produits
- Informations sur les médicaments cliniques
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