GAD2

GAD2 Informations sur la molécule

Nom anglais	Glutamate decarboxylase 2	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
Phase de R&D la plus avancée	Pending

Nom anglais	Glutamate decarboxylase 2
Alias de la cible	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Pending

GAD2 Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
GA2-H55H3	Human	InsectCells	Human GAD2 / GAD65 Protein, His Tag				Ajouter au panier

Quantité totale1

Demande de produit

GAD2Contexte de la molécule

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets. GAD uses pyridoxal-phosphate (PLP) as a cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.