GDF-2

GDF-2 Informations sur la molécule

Nom anglais	Growth/differentiation factor 2	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	GDF-2，BMP-9，BMP9，HHT5，Bone Morphogenetic Protein 9
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Growth/differentiation factor 2
Alias de la cible	GDF-2，BMP-9，BMP9，HHT5，Bone Morphogenetic Protein 9
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

GDF-2 Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
Tag Free (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
GD2-H5211	Human	HEK293	Human GDF-2 Protein, Tag Free				Ajouter au panier

Quantité totale1

GDF-2Contexte de la molécule

Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.