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Menu
Home PageAll MoleculesgH&gL
gH&gL
gH&gL Product List
- Product Category
Antibody (1)
- Product Status
Launched (1)
- Species
Mouse (1)
- Tag
- (1)
- Conjugate
Unconjugated (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
GHL-MY2111 |  Mouse | HEK293 | Monoclonal Anti-VZV gH & gL Antibody, Human IgG1 (4F12) (MALS verified) |  |
Total: 1
- 1
gH&gL Background
Varicella-zoster virus (VZV) is the alphaherpesvirus that causes chicken pox (varicella) and shingles (zoster). As for all herpesviruses, VZV relies on a fusion complex comprised of three core glycoproteins, gB, gH and gL, required for entry of virions into host cells. VZV ORFs 37 and 60 encode gH (841aa; 118 kDa) and gL (160aa; 20 kDa), respectively, which are N- and O-linked glycosylated and form a heterodimer that is necessary for the activation of gB.
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| XCUR-17 | XCUR-17 | Phase 1 Clinical | Exicure Inc | Psoriasis | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Brodalumab | IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 | Approved | Amgen Inc | Siliq, Lumicef, Kyntheum, 立美芙 | Japan | Psoriasis; Arthritis, Psoriatic | Kyowa Kirin Co Ltd | 2016-07-04 | Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details |
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