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Page d'accueilToutes les moléculesGlypican 2
Glypican 2
Glypican 2 Informations sur la molécule
| Nom anglais | Glypican-2 | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 2 | Alias de la cible | Cerebroglycan，Glypican Proteoglycan 2， Cerebroglycan Proteoglycan |
| Phase de R&D la plus avancée | Phase 1 Clinical | ||
| Nom anglais | Glypican-2 |
| Alias de la cible | Cerebroglycan，Glypican Proteoglycan 2， Cerebroglycan Proteoglycan |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 2 |
| Phase de R&D la plus avancée | Phase 1 Clinical |
Glypican 2 Liste de produits
- Attribut
Protein (7)
- Bibliothèque de produits
En ligne (7)
- Espèces
Human (4)Mouse (1)Rhesus macaque (2)
- Étiquette
His Tag (3)Fc Tag (1)Llama IgG Fc Tag (1)His Tag & Avi Tag (2)
- Marqueur
Unconjugated (5)Biotin-labeled (2)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
HOT GP2-H5255 |  Human | HEK293 | Human Glypican 2 / GPC2 Protein, Fc Tag (SPR verified) |  |  |  |  Ajouter au panier |
HOT GP2-H52H3 | Human | HEK293 | Human Glypican 2 / GPC2 Protein, His Tag, low endotoxin |  | |  | Ajouter au panier |
HOT GP2-H82E3 | Human | HEK293 | Biotinylated Human Glypican 2 / GPC2 Protein, His,Avitag™ (MALS verified) |  | | | Ajouter au panier |
HOT GP2-M52H5 |  Mouse | HEK293 | Mouse Glypican 2 / GPC2 Protein, His Tag |  | | | Ajouter au panier |
| Human | HEK293 | Human Glypican 2 / GPC2 Protein, Llama IgG2b Fc Tag, low Endotoxin |  | | | Ajouter au panier | |
 Rhesus macaque | HEK293 | Rhesus macaque Glypican 2 / GPC2 Protein, His Tag |  | | | Ajouter au panier | |
| Rhesus macaque | HEK293 | Biotinylated Rhesus macaque Glypican 2 / GPC2 Protein, His,Avitag™ (MALS verified) |  | | | Ajouter au panier |
Quantité totale7
- 1
Glypican 2Contexte de la molécule
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
Glypican 2Alias de la molécule
Glypican 2,GPC2
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| anti-glypican-2 CAR T-cell therapy (Childrens Hospital of Philadelphia/Kite Pharma) | Phase 1 Clinical | Childrens Hospital of Philadelphia | Rhabdomyosarcoma; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Neuroblastoma | Details | |
| GPC2 CAR-T cell therapy(Childrens Hospital of Philadelphia/Tmunity Therapeutics) | TmGPC2-01-CAR-T | Phase 1 Clinical | Childrens Hospital of Philadelphia | Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Neuroblastoma | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments cliniques
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