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Glypican 3

Glypican 3

Glypican 3 Overview

Molecule Name
Glypican-3
Synonyms
GPC3,OCI5,Glypican-3,GTR2-2,MXR7,DGSX,SDYS ,SGB,SGBS,SGBS1
Drug Development Progress
Drugs in Clinical Trials58
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
MXR7，OCI5，GPC3，Glypican-3，Glypican 3，Glypican Proteoglycan 3，GTR2-2，Secreted Glypican-3，OCI-5，SGBS1，DGSX，SGBS，SDYS，SGB，Intestinal protein OCI-5，Heparan Sulphate Proteoglycan
Background
Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

Glypican 3 Product List

Species
  • Human（16）
  • Cynomolgus（3）
  • Mouse（3）
  • Rat（1）
Tag
  • His Tag（15）
  • Fc Tag（5）
  • Llama IgG Fc Tag（2）
  • His Tag & Avi Tag（1）
Host
  • HEK293（23）
Conjugate
  • Unconjugated（14）
  • APC Labeled（3）
  • FITC Labeled（2）
  • PE Labeled（2）
  • AF488 Labeled（1）
  • Biotin-labeled（1）
Grade
  • RUO（20）
  • PG (pre-GMP)（3）
Low Endotoxin
  • Yes（6）
  • No（17）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
Glypican 3
HOT
GP3-HF258
FITC-Labeled Human Glypican 3 / GPC3 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISAFlow

$345.00

25ug
Glypican 3
HOTAvitag
GP3-H82E5
Biotinylated Human Glypican 3 / GPC3 Protein, His,Avitag™, premium grade
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$260.00

25ug
Glypican 3
HOTAIDD‑Ready
GP3-H52H4
Human Glypican 3 / GPC3 Protein, His Tag, premium grade
Human
HEK293
MALSSDS-PAGE
ELISASPRBLIFlow

$380.00

100ug
Glypican 3
HOT
GP3-HA2H9
APC-Labeled Human Glypican 3 / GPC3 Protein, His Tag (Site-specific conjugation)
Human
HEK293
Flow

$360.00

25tests
Glypican 3
GP3-C5225
Cynomolgus Glypican 3 / GPC3 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$535.00

100ug
Glypican 3
GP3-C5256
Cynomolgus Glypican 3 / GPC3 Protein, Fc Tag, low endotoxin
Cynomolgus
HEK293
SDS-PAGE
ELISA

$300.00

100ug
Glypican 3
GP3-C5259
Cynomolgus Glypican 3 / GPC3 Protein, Llama IgG2b Fc Tag, low endotoxin
Cynomolgus
HEK293
SDS-PAGE
ELISA

$360.00

100ug
Glypican 3
AIDD‑Ready
GP3-H5223
Human Glypican 3 / GPC3 (S359F) Protein, His Tag
Human
HEK293
SDS-PAGE
ELISASPRBLI

$330.00

100ug
Glypican 3
GP3-H5255
Human Glypican 3 / GPC3 (R355A,R358A) Protein, Fc Tag, premium grade
Human
HEK293
MALSSDS-PAGE
ELISACELL BASE

$310.00

100ug
Glypican 3
GP3-H5257
Human Glypican 3 / GPC3 Protein, Llama IgG2b Fc Tag, low endotoxin
Human
HEK293
SDS-PAGE
ELISA

$360.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
GPC-3298306GPC-3298306Phase 2 ClinicalNational Cancer Center Of Japan
Carcinoma, Hepatocellular; Ovarian Neoplasms
Details
BOS-342PRS-342; BOS-342; PRS-342/BOS-342Phase 2 ClinicalPieris Pharmaceuticals
Carcinoma, Hepatocellular; Solid tumours
Details
BOXR-1030BOXR-1030Phase 2 ClinicalUnum Therapeutics Inc
Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Liposarcoma, Myxoid; Liver Neoplasms; Lung Neoplasms
Details
GPC3 targeting CAR-T cell therapy (Essen Biotech)Phase 2 ClinicalEssen Biotech
Carcinoma, Ovarian Epithelial; Ovarian Neoplasms
Details
AZD-9793AZD9793; AZD-9793Phase 2 ClinicalAstrazeneca Plc
Carcinoma, Hepatocellular; Neoplasm Metastasis; Solid tumours
Details
CAR-T Cell Therapy Targeting GPC3(Pla General Hospital)Phase 2 ClinicalPla General Hospital
Carcinoma, Hepatocellular
Details
MRG-006MRG-006A; MRG-006Phase 2 ClinicalShanghai Miracogen Inc
Carcinoma, Hepatocellular; Liver Neoplasms; Neoplasms; Solid tumours
Details
C-CAR031C-CAR031; AZD-7003; TC-CAR-031; TC-CAR031; C-CAR-031Phase 2 ClinicalAstrazeneca Plc
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung
Details
NY-303NY-303Phase 2 ClinicalNAYA Biosciences Inc
Carcinoma, Hepatocellular; Solid tumours
Details
AZD-5851AZD-5851; AZD5851Phase 2 ClinicalAstrazeneca Plc
Carcinoma, Hepatocellular
Details
NWRD-06NWRD-06; NWRD06Phase 2 ClinicalNewish Technology (Beijing) Co Ltd
Carcinoma, Hepatocellular
Details
GKL-006GKL-006; GKL006Phase 2 ClinicalBeijing Gene Key Life Technology Co Ltd
Carcinoma, Hepatocellular; Liver Neoplasms; Pancreatic Neoplasms; Psoriasis
Details
CMD-011CMD-011Phase 2 ClinicalZhejiang Shimai Pharmaceutical Co Ltd
Carcinoma, Hepatocellular; Liver Neoplasms
Details
CAR-GPC3 T-cell (Drum Tower Hospital)Phase 2 ClinicalNanjing Drum Tower Hospital
Carcinoma, Hepatocellular
Details
GPC3 CAR-T therapy (Hrain Biotechnology)Phase 2 ClinicalHrain Biotechnology Co Ltd
Carcinoma, Hepatocellular
Details
CM-350CM-350Phase 2 ClinicalKeymed Biosciences Co Ltd
Solid tumours
Details
GPC3-CAR-T cell therapy(Origincell Medical Technology)Ori-CAR-001; Ori-C101（OriCell）Phase 2 ClinicalOriCell Therapeutics Co Ltd
Carcinoma, Hepatocellular
Details
ECT-204ECT-204; JWATM-204; ECT204Phase 2 ClinicalEureka Therapeutics Inc, Jw Therapeutics (Shanghai) Co Ltd
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Neoplasms
Details
CodrituzumabGC-33; RO-5137382; RG-7686; ERY-974; PPMX-T001Phase 1 ClinicalPerseus Proteomics Inc
Carcinoma, Hepatocellular; Solid tumours
Details
GPC3-T2 CAR-T cell therapy (The Second Affiliated Hospital of Guangzhou Medical University)Phase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical University
Carcinoma, Hepatocellular; Carcinoma, Squamous Cell
Details
GLYCAR T cell therapy (Baylor College of Medicine)GLYCARPhase 1 ClinicalBaylor College Of Medicine
Carcinoma, Hepatocellular; Endodermal Sinus Tumor; Hepatoblastoma; Liposarcoma; Liver Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Wilms Tumor
Details
Anti-GPC3 CAR T-cell therapy (Carbiogene Therapeutics)CBG166; CBG-166Phase 1 ClinicalCarbiogene Therapeutics Co Ltd, Nanjing University
Carcinoma, Hepatocellular
Details
GPC3-CAR-T cell therapyCSG-GPC-3; CAR-GPC3 T-cell; GPC3-CAR/CSG-GPC3; anti-GPC-3 CAR T; KJgpc3-001; CT-011Phase 1 ClinicalCarsgen Biomedicine (Shanghai) Co Ltd
Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Solid tumours
Details
Anti-GPC3 chimeric antigen receptor T cell therapy (Hunan Zhaotai Yongren Biotech/Guangdong Zhaotai Invivo Biomedicine)Phase 1 ClinicalGuangdong Zhaotai Invivo Biomedicine Co Ltd, Hunan Zhaotai Yongren Biotech Co Ltd
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung
Details
anti-GPC3 CAR T-cell therapy (National Institutes of Health Clinical Center)Phase 1 ClinicalNational Institutes Of Health Clinical Center (Cc)
Carcinoma, Hepatocellular
Details
anti-GPC3 CAR T-cell therapy (Nanjing Drum Tower Hospital)Phase 1 ClinicalNanjing Drum Tower Hospital
Carcinoma, Hepatocellular
Details
GPC3-T2-CAR-TGPC3-T2-CAR-TPhase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical University
Carcinoma, Hepatocellular
Details
EU-307EU307Phase 1 ClinicalEutilex
Carcinoma, Hepatocellular; Liver Neoplasms
Details
Ori-CAR-002Ori-CAR-002; GPC3-CAR-Ori2Phase 1 ClinicalOriCell Therapeutics Co Ltd
Multiple Myeloma
Details
SENTI-301SENTI-301; SENTI-301A; SN301APhase 1 ClinicalSenti Biosciences Inc
Carcinoma, Hepatocellular; Liver Neoplasms
Details
Super CAR-T cell therapy (FineImmune Biotechnology)Phase 1 ClinicalGuangzhou Fineimmune Biotechnology
Carcinoma, Hepatocellular
Details
TC-G203TC-G203; TCG203Phase 1 ClinicalBeijing GoBroad Hospital
Carcinoma, Hepatocellular; Solid tumours
Details
I-124 CodrituzumabPhase 1 ClinicalChugai Pharmaceutical Co Ltd, Hoffmann-La Roche Inc, Memorial Sloan Kettering Cancer Center
Carcinoma, Hepatocellular
Details
225Ac-RYZ-811225Ac-RYZ-811Phase 1 ClinicalPeptiDream Inc
Carcinoma, Hepatocellular
Details
OriC-902OriC-902; OriC902Phase 1 ClinicalOriCell Therapeutics Co Ltd
Carcinoma, Hepatocellular
Details
BAY-3547926BAY3547926; BAY-3547926Phase 1 ClinicalBayer AG
Carcinoma, Hepatocellular
Details
MT-303(Myeloid)MT-303(Myeloid)Phase 1 ClinicalMyeloid Therapeutics Inc
Carcinoma, Hepatocellular
Details
68Ga-aGPC3-scFv/Fab68Ga-aGPC3-scFv/FabPhase 1 ClinicalWuhan Union Hospital
Liver Neoplasms
Details
BGB-B2033BGB-B-2033; BGB-B2033Phase 1 ClinicalBeigene Guangzhou Biologics Manufacturing Co Ltd
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Solid tumours; Stomach Neoplasms
Details
BC-2027BC2027; BC-2027Phase 1 ClinicalWuxi BioCity
Liver Neoplasms; Solid tumours
Details
JMT-106JMT106; JMT-106Phase 1 ClinicalCSPC Pharmaceutical Group Ltd
Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Solid tumours
Details
AST-201 (Aptamer Sciences)AST-201(Aptamer Sciences)Phase 1 ClinicalAptamer Sciences Inc
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Neoplasms; Neoplasms; Solid tumours
Details
GPC3/Mesothelin-CAR-γδT Cells therapy(Second Affiliated Hospital Of Guangzhou Medical University)Phase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical University
Liver Neoplasms; Lung Neoplasms; Mesothelioma; Pancreatic Neoplasms; Solid tumours
Details
ZW-251ZW-251Phase 1 ClinicalZymeworks Inc
Carcinoma, Hepatocellular
Details
68Ga-RYZ-811RYZ811(68Ga); 68Ga-Ga-RYZ-GPC3; 68Ga-GPC3; 68Ga-RYZ-811; RYZ-811Phase 1 ClinicalPeptiDream Inc, RayzeBio Inc
Carcinoma, Hepatocellular
Details
GPC3-targeted CAR-T (Peking University)Phase 1 ClinicalPeking University
Carcinoma, Hepatocellular
Details
CAR (hYP7)-T cells (National Cancer Institute)Phase 1 ClinicalNational Cancer Institute
Carcinoma, Hepatocellular
Details
QLS-31903QLS31903; QLS-31903Phase 1 ClinicalQilu Pharmaceutical Co Ltd
Solid tumours
Details
SAR-444200SAR-444200Phase 1 ClinicalSanofi
Neoplasms; Solid tumours
Details
IM-83 CAR-T cell therapyIM-83; IM83Phase 1 ClinicalImunopharm Technology Co Ltd
Carcinoma, Hepatocellular; Liver Neoplasms; Neoplasms; Osteosarcoma
Details
JWATM-214JWATM-214; JWATM214Phase 1 ClinicalSuzhou Yaomingjunuo Biotechnology Co Ltd
Carcinoma, Hepatocellular; Liver Neoplasms
Details
TH-012(Bangentai Biomedical)TH-012Phase 1 ClinicalShandong Bangentai Biomedical Tech Group Co Ltd
Pancreatic Neoplasms; Stomach Neoplasms
Details
B010-AB010-APhase 1 ClinicalShanghai Pharmaceuticals Holding Co Ltd
Carcinoma, Hepatocellular
Details
CT-0180CT-0180Phase 1 ClinicalCARsgen Therapeutics Holdings Ltd
Carcinoma, Hepatocellular
Details
HRAIN-011HRAIN-011ClinicalHrain Biotechnology Co Ltd
Carcinoma, Hepatocellular
Details
[68Ga]Ga-NOTA-G5ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Digestive System Neoplasms
Details
[18F]F-RESCA-G5ClinicalRenji Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Digestive System Neoplasms
Details
Anti-GPC3-IRDye800CWClinicalChinese Academy Of Sciences
Details
Customer Reviews
  • 1***62019-10-11
    FITC-Labeled Human Glypican 3 / GPC3 Protein, Fc Tag
    GPC3 is also currently a popular target for solid tumors. I bought this product to detect the positive rate of CAR-T cells. The result was the same with the one performed using our own purified expressed protein (added hFc tag, which requires fluorescent labeled secondary antibodies). But no need to dye for secondary antibodies, so this one from ACRO was more convenient.