Select Language
Trending Searches:
My Cart
- Home
- ProductsSearch by Product
- Recombinant ProteinsRecombinant Proteins
- Immune Checkpoints
- Autoimmune Disease Targets
- Metabolic Disease Targets
- Cytokine Targets
- GMP-grade Proteins
- Cell Therapy Targets
- Fc Receptor Proteins
- ADC Target Proteins
- Enzymes
- Proteins for Neuroscience
- Multi-pass Transmembrane Proteins
- Tumor Microenvironment Proteins
- Other Proteins
- AntibodiesAntibodies
- Immunohistochemistry (IHC) Antibodies
- Antibody Services
- Isotype Controls
- Anti-payload Antibodies
- Universal Antibodies
- Anti-idiotype Antibodies
- Other Antibodies
- Cell Lines
- Cell Culture ReagentsCell Culture Reagents
- GMP-grade Growth Factors
- Activation Antibodies
- Extracellular Matrix (ECM) Proteins
- Serum-free Cell Culture Medium
- Disposable Accessories
- Cell Culture Grade Magnetic Beads
- Nuclease
- Solutions
- Complete Solutions from Research to Clinical ManufacturingCytoPak Bag Solution for Closed SystemsCMC Production Process of Adoptive T Cell TherapiesCMC Production Process of Adoptive NK Cell TherapyCMC Production Process of iPSC-based Cell TherapyCMC Manufacturing Process Solutions for HSPC-Based Cell TherapiesHigh Quality Laminin Protein Supports Clinical iPSC BankingExtracellular Matrix (ECM) ProteinsCytokines for Stem Cell TherapyCytokines for Organoid CultureAneuro - Neural FactorsOrganoid ToolboxKey Raw Materials for Cell & Gene Therapy
- Others
- Kits & Assay ReagentsKits & Assay Reagents
- ELISA Kits
- Autoimmune Biomarker Detection KitTumor Biomarker Detection KitStem Cell & Organoid Biomarker Detection KitCytokine Detection KitsMetabolic Disease Biomarker Detection KitINHBE/Activin E Dimer ELISA KitHuman Erythropoietin (EPO) ELISA KitBiomarker Detection KitsInhibitor Screening KitsAAV-related assay kitsImmunogenicity Assay KitsPK Assay KitsEnzyme-Linked Immunosorbent Assay (ELISA) ServiceBridging ELISA Kits
- qPCR Kits
- Fluorescence Assay Kits
- TR-FRET Kits
- Flow Cytometry Assay Kits
- ADC Conjugation Kits
- Antibody Internalization Detection & Labeling Kits
- Intact ADC Quantification ELISA Kits
- ELISpot Kits
- Assay Reagents
- Viral Antigens&Antibodies & KitsViral Antigens&Antibodies & Kits
- Nipah Virus
- Varicella Zoster Virus
- Influenza Virus
- Respiratory Syncytial Virus
- Rabies Virus
- Herpes Virus
- Other Viruses
- ViruStop Services
- SARS-CoV-2
- Organoids-related SolutionsOrganoids-related Solutions
- Ready-to-use Organoids
- Organoid Technical Services
- Organoid Culture Reagents
- Other Related Products
- OthersOthers
- Lab Reagents
- Experimental Instruments and Equipments
Search by Modality- Cell TherapyCell Therapy
- Discovery & Development
- Cell Culture Products
- CAR Targets
- Universal CAR Detection Tool
- Other Target Proteins
- General Proteins
- Drug Screening Service
- Early Pharmacodynamic Assessment
- Immunohistochemistry (IHC) Antibodies
- Manufacturing
- GMP-grade Growth Factors
- Extracellular Matrix (ECM) Proteins
- Serum-free Cell Culture Medium
- Disposable Accessories
- Cell Activation
- Gene Editing
- Residual Nucleic Acid Removal
- Solutions
- - Complete Solutions from Research to Clinical Manufacturing
- - CytoPak Bag Solution for Closed Systems
- - CMC Production Process of Adoptive T Cell Therapies
- - CMC Production Process of Adoptive NK Cell Therapy
- - CMC Production Process of iPSC-based Cell Therapy
- - CMC Manufacturing Process Solutions for HSPC-Based Cell Therapies
- - High Quality Laminin Protein Supports Clinical iPSC Banking
- - Extracellular Matrix (ECM) Proteins
- - Cytokines for Stem Cell Therapy
- - Cytokines for Organoid Culture
- - Aneuro - Neural Factors
- - Organoid Toolbox
- - Key Raw Materials for Cell & Gene Therapy
- - GMP Grade vs Premium(Pre-GMP) Grade
- Custom GMP-grade Products
- GMP-Resilient Supply
- Quality Control
- CAR Target Proteins
- Anti-Linker Antibodies
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- CMC Residue Detection Kits
- - Residual Host Cell DNA Detection Kits
- - Residual Plasmid DNA Quantitation Kit
- - RNase / DNase Detection Kits
- - Residual dsRNA ELISA Kit
- - Residual T7 RNA polymerase ELISA Kit
- - Residual BSA ELISA Kit
- - Residual Antibiotics Detection Kits
- - Residual HIV-1 p24 ELISA Kit
- - Residual Cell Culture Materials Detection Kits
- - Human Laminin Quantitative ELISA Kit
- - CGT CMC Manufacturing Process Residue Detection Solutions
- - More >>
- Flow Cytometry Analysis Platform
- - Human Th1/Th2 Cytokine Kit
- - Human TBNK 6-color Cocktail Flow Panel
- - Fluorescent Labeled CAR Target Protein
- - Anti-Linker Antibodies
- - Anti-FMC63 scFv Antibodies
- - Anti-C11D5.3 scFv Antibodies
- - MHC Tetramer
- - Antibody Labeling Kit
- - Single/Multiplex Cytokine Flow Cytometry Analysis Platform
- - Cell Phenotyping Flow Cytometry Analysis Platform
- - Star Staining New-generation Site-specific Labeling Platform
- - More >>
- Antibody Density Detection on Carriers
- - Alexa Fluor™ 488-Labeled Human CD3 epsilon Protein, His Tag
- - Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His Tag
- - Alexa Fluor™ 488-Labeled Human CD5 Protein, His Tag Star Staining
- - Alexa Fluor™ 488-Labeled Human CD4 Protein, His Tag Star Staining
- - Alexa Fluor™ 488-Labeled Human CD7 Protein, His Tag Star Staining
- - More >>
- ELISA Kits
- Functional Cell lines (Cellinsight)
- Pre-clinical Research
- Pharmacokinetics Studies
- Pharmacodynamics Studies
- Toxicity Studies
- Immunogenicity Studies
- Audit & Documentation support
- Immunohistochemistry (IHC) Antibodies
- Clinical Research
- Pharmacokinetics Studies
- Biomarker and Translational Research
- Toxicity Studies
- Immunogenicity Studies
- Immunohistochemistry (IHC) Antibodies
- In Vivo CARIn Vivo CAR
- Discovery & Development
- Antibody Density Detection on Carriers
- - Alexa Fluor™ 488-Labeled Human CD3 epsilon Protein, His Tag
- - Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His Tag
- - Alexa Fluor™ 488-Labeled Human CD5 Protein, His Tag Star Staining
- - Alexa Fluor™ 488-Labeled Human CD4 Protein, His Tag Star Staining
- - Alexa Fluor™ 488-Labeled Human CD7 Protein, His Tag Star Staining
- - More >>
- tLNP Delivery Characterization
- CAR Target Proteins
- Universal CAR Detection Tool
- Early Pharmacodynamic Assessment
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- Manufacturing
- Residual Nucleic Acid Removal
- Quality Control
- Antibody Density Detection on Carriers
- - Alexa Fluor™ 488-Labeled Human CD3 epsilon Protein, His Tag
- - Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His Tag
- - Alexa Fluor™ 488-Labeled Human CD5 Protein, His Tag Star Staining
- - Alexa Fluor™ 488-Labeled Human CD4 Protein, His Tag Star Staining
- - Alexa Fluor™ 488-Labeled Human CD7 Protein, His Tag Star Staining
- - More >>
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- CMC Residue Detection Kits
- Pre-clinical Research
- Pharmacokinetic Studies
- Immunogenicity Studies
- Toxicity Studies
- Immunohistochemistry (IHC) Antibodies
- Pharmacodynamic Assessment
- Clinical Research
- Pharmacokinetic Studies
- Immunogenicity Studies
- Toxicity Studies
- Immunohistochemistry (IHC) Antibodies
- Biomarker and Translational Research
- Gene TherapyGene Therapy
- Discovery & Development
- Gene Editing
- Early Pharmacodynamic Assessment
- AAV Titer Quantitation
- Pre-existing anti-AAV Antibody Research
- Manufacturing
- Premium(Pre-GMP) grade Raw Materials
- Gene Editing Products
- Nucleic Acid Removal Products
- AAV Titer Quantitation
- Large-Scale Manufacturing
- Quality Control
- AAV Titer Quantitation
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- Residual Detection-resDetect
- Potency Assays
- Pre-clinical Research
- Pharmacodynamics Studies
- Immunogenicity Studies
- Toxicity Studies
- Audit & Documentation support
- Clinical Research
- Biomarker and Translational Research
- Toxicity Studies
- Immunogenicity Studies
- Therapeutic AntibodiesTherapeutic Antibodies
- Discovery & Development
- Target Proteins
- Antibody Screening
- Fc Proteins
- Cell Line (CellInsight)
- Early Pharmacodynamic Assessment
- Immunohistochemistry (IHC) Antibodies
- TR-FRET Kits
- Manufacturing
- Nucleic Acid Removal
- High-yield Monoclonal Clones Screening
- Quality Control
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- Residual Detection-resDetect
- Other Quality Control Products
- Cytokine Release Detection
- Preclinical Research
- Pharmacokinetics Studies
- Toxicity Studies
- Immunogenicity Studies
- Pharmacodynamics Studies
- Audit & Documentation support
- Immunohistochemistry (IHC) Antibodies
- Clinical Research
- Pharmacokinetics Studies
- Biomarker and Translational Research
- Immunogenicity Studies
- Toxicity Studies
- Immunohistochemistry (IHC) Antibodies
- Antibody Drug ConjugatesAntibody Drug Conjugates
- Discovery & Development
- Antibody Screening
- Internalization Analysis & Mechanistic Studies
- Fc Effector Function Validation
- Linker Screening and Validation
- Early Pharmacodynamic Assessment
- TR-FRET Kits
- Manufacturing
- Conjugation Kits
- Quality Control
- Internalization Analysis & Mechanistic Studies
- Fc Effector Function Validation
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- Residual Detection
- Enzymes for Antibody Characterization
- Antibody Characterization Services
- Pre-clinical Research
- Pharmacokinetics Studies
- Pharmacodynamics Studies
- Immunogenicity Studies
- Toxicity Studies
- Audit & Documentation support
- Immunohistochemistry (IHC) Antibodies
- Clinical Research
- Pharmacokinetics Studies
- Biomarker and Translational Research
- Toxicity Studies
- Immunogenicity Studies
- Immunohistochemistry (IHC) Antibodies
- VaccinesVaccines
- Discovery & Development
- Recombinant Viral Antigens-ViruStop
- Antigen Detection
- Vaccine Efficacy Assessment
- Early Pharmacodynamic Assessment
- Manufacturing
- Gene-editing
- Quality Control
- Antigen Detection
- Vaccine Efficacy Assessment
- Safety Testing Platform
- - Recombinant Factor C Endotoxin Detection Kit
- - Recombinant Factor C Endotoxin Detection Kit (High Sensitivity)Coming Soon
- - LER Sample Dilution Buffer
- - Endotoxin-Free Glass Test Tubes
- - Mycoplasma DNA Sample Preparation Kit (Magnetic beads)
- - Mycoplasma Rapid Detection Kit (qPCR)
- - Sterility Sample Preparation Kit (Magnetic beads)
- - Sterility Rapid Detection Kit (qPCR)
- - Automated Nucleic Acid Extraction System
- - Nuclease-Free Water
- - 96 V-Bottom Deep-well Plate
- - 8-Strip V-Bottom Tip Comb
- - More >>
- Residual Detection-resDetect
- - Vero resDNA Quantitation Kit (qPCR)
- - Pichia pastoris resDNA Quantiation Kit(qPCR)
- - Host DNA/Protein Quantitative Kits
- - RNase / DNase Detection Kits
- - GENIUS™ Nuclease Residual Detection Kit
- - Residual Raw Enzyme Materials Detection Kits
- - Residual dsRNA ELISA Kit
- - Residual BSA ELISA Kit
- - Residual Antibiotics Detection Kits
- - More >>
- Pre-clinical Research
- Clinical Research
- Vaccine Efficacy Assessment
- Toxicity Studies
- Biomarker and Translational Research
Explore by Brand- All Brands
- ServicesTechnical Service Platform
- Custom Development ServicesCustom Development ServicesMore >
- Custom GMP-grade Protein Services
- TR-FRET Kit Development Service
- MHC Complex Custom Service
- Enzyme-Linked Immunosorbent Assay (ELISA) Service
- Cell line customization service
- Recombinant Antibody Services
- Single B Cell Antibody Discovery Platform
- Anti-Idiotypic Antibody Development Service
- Biomarker Immunoassay Development Services
- Immunohistochemistry (IHC) Antibody Customization Services
- Analytical Testing ServicesAnalytical Testing ServicesMore >
- SAFENSURE™ Safety Testing Services
- Enzyme-Linked Immunosorbent Assay (ELISA) Service
- Biomolecular Interaction Analysis Service
- Quality Characterization Analytical Service
- Reporter Cell Line Validation Service
- Other ServicesOther Services
- Functional Cell Line Commercial License Support
- Quality
Quality Management Systems
GMP-Resilient Supply
“Structure & Application Integrated” Protein Development Platform
- Activities
- Resources
- Supports
- ACROBiosystems
About Us
Partner with Us
Contact Us
Other Information
Menu
Home PageAll MoleculesGUCY2C
GUCY2C
GUCY2C Overview
| English Name | Heat-stable enterotoxin receptor | Approved Drugs | 1 |
| Drugs in Clinical Trials | 9 | Target Synonym | GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL |
| Highest Development Stage | Approved | ||
| English Name | Heat-stable enterotoxin receptor |
| Target Synonym | GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL |
| Approved Drugs | 1 |
| Drugs in Clinical Trials | 9 |
| Highest Development Stage | Approved |
GUCY2C Product List
- Product Category
Protein (21)Cell (1)Antibody (1)
- Product Status
Launched (22)In Research (1)
- Species
Human (15)Mouse (4)Cynomolgus (3)Rabbit (1)
- Tag
Fc Tag (4)His Tag (13)Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)- (2)
- Conjugate
Unconjugated (8)FITC Labeled (3)Biotin-labeled (4)PE Labeled (2)AF488 Labeled (1)APC Labeled (2)AF647 Labeled (1)AF555 Labeled (1)- (1)
Total: 23
- 1
- 2
- 3
GUCY2C Background
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
GUCY2C Synonyms
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Project Cooperation
| Project Name | Drug Type | Therapeutic Area | Indication | Stage | Rights Area |
|---|---|---|---|---|---|
| Anti-GCC humanized antibody | Bispecific antibody | Oncology/Cancer | Solid Tumor | Preclinical | Global |
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| anti-GUCY2C CAR T-cell therapy (Parasol Biotechnology/Anhui provincial cancer hospital) | Phase 1 Clinical | HeFei Parasol Biotech Co Ltd | Colorectal Neoplasms | Details | |
| anti-guanylyl cyclase C CAR-T cell therapy (Legend Biotech) | LCAR-G08T | Phase 1 Clinical | Legend Biotech Corp | Colorectal Neoplasms; Gastrointestinal Neoplasms | Details |
| HD-006 | HD006; HD-006 | Phase 1 Clinical | Huadao (Shanghai) Biopharma Co Ltd | Solid tumours | Details |
| REVO-UWD-01 | REVO-UWD-01; WD 01 | Phase 1 Clinical | Wondercel Therapeutics Co Ltd | Colorectal Neoplasms | Details |
| IM96 CAR-T cell Therapy | IM96 | Phase 1 Clinical | Imunopharm Technology Co Ltd | Colorectal Neoplasms; Digestive System Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms | Details |
| GCC19CART | GCC19CART; LYL273; LYL-273 | Phase 1 Clinical | Innovative Cellular Therapeutics Co Ltd | Colorectal Neoplasms; Rectal Neoplasms | Details |
| Gucy2c cart cell therapy (Innovative Cellular Therapeutics) | Phase 1 Clinical | Innovative Cellular Therapeutics Co Ltd | Digestive System Neoplasms | Details | |
| XKDCT-080 | XKDCT-080 | Clinical | The Affiliated Hospital Of Qingdao University | Colonic Neoplasms; Solid tumours | Details |
| CT-080 | CT-080 | Clinical | Shenzhen Celconta Life Science Co Ltd | Solid tumours | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Plecanatide | SP-304; GCRA | Approved | Synergy Pharmaceuticals Inc | Trulance | United States | Constipation; Chronic idiopathic constipation | Salix Pharmaceuticals | 2017-01-19 | Chronic idiopathic constipation; Constipation; Irritable Bowel Syndrome | Details |
- Overview
- Product List
- Marketed Drug Information
- Clinical Drug Information
Share to: