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Page d'accueilToutes les moléculesH-2Kd & B2M & InsB (LYLVCGERL)
H-2Kd & B2M & InsB (LYLVCGERL)
H-2Kd & B2M & InsB (LYLVCGERL) Liste de produits
- Attribut
Protein (1)
- Bibliothèque de produits
En ligne (1)
- Espèces
Mouse (1)
- Étiquette
His Tag & Avi Tag (1)
- Marqueur
Biotin-labeled (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
H2B-M82E3 |  Mouse | HEK293 | Biotinylated Mouse H-2Kd&B2M&InsB (LYLVCGERL) Complex Protein (Monomer, MALS verified) |  |  Ajouter au panier |
Quantité totale1
- 1
H-2Kd & B2M & InsB (LYLVCGERL)Contexte de la molécule
The peptide LYLVCGERL, derived from mouse insulin B chain (InsB), is presented by the H-2Kd/β2-microglobulin (β2m) complex. This complex is a central autoantigen in the non-obese diabetic (NOD) mouse model of type 1 diabetes. Recognition of this peptide-MHC complex by autoreactive CD8⁺ T cells is a critical early event in the destruction of insulin-producing pancreatic beta cells, making it a fundamental target for studying autoimmune diabetes pathogenesis and tolerance mechanisms.
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| PF-06730512 | PF-06730512 | Phase 1 Clinical | Pfizer Inc | Glomerulosclerosis, Focal Segmental | Details |
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