HLA-A*0201 & B2M & Survivin (LTLGEFLKL)

The HLA-A*02:01&B2M&Survivin (LTLGEFLKL) complex is a key antigen-presenting complex in the immune system. HLA-A*02:01, a major histocompatibility complex (MHC) class I molecule, forms a stable heterodimer with β2-microglobulin (B2M). Subsequently, this dimer binds to the Survivin-derived peptide LTLGEFLKL—a specific epitope of Survivin, an anti-apoptotic protein overexpressed in various tumors. This complex is critical for activating cytotoxic T lymphocytes (CTLs), enabling the immune system to recognize and eliminate tumor cells expressing Survivin.