HVEM

HVEM Informations sur la molécule

Nom anglais	Tumor necrosis factor receptor superfamily member 14	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0	Alias de la cible	Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
Phase de R&D la plus avancée	Preclinical

Nom anglais	Tumor necrosis factor receptor superfamily member 14
Alias de la cible	Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0
Phase de R&D la plus avancée	Preclinical

HVEM Liste de produits

Attribut
Protein (4)Cell (3)
Bibliothèque de produits
En ligne (7)
Espèces
Human (7)
Étiquette
Fc Tag (1)His Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (3)
Marqueur
Unconjugated (3)Biotin-labeled (1)- (3)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT HVM-H5257	Human	HEK293	Human HVEM / TNFRSF14 Protein, Mouse IgG2a Fc Tag (MALS verified)	Ajouter au panier
HOT HVM-H5258	Human	HEK293	Human HVEM / TNFRSF14 Protein, Fc Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT HVM-H52E9	Human	HEK293	Human HVEM / TNFRSF14 Protein, His Tag (MALS verified)	Ajouter au panier
HOT HVM-H82F6	Human	HEK293	Biotinylated Human HVEM / TNFRSF14 Protein, Fc,Avitag™ (MALS verified)	Ajouter au panier
CHEK-ATF105	Human	HEK293	Human HVEM (Luc) HEK293 Reporter Cell	Ajouter au panier
CHEK-ATP147	Human	HEK293	HEK293/Human HVEM Stable Cell Line	Ajouter au panier
SCRAJ-STF108	Human	Raji	Raji/Human HVEM Stable Cell Line	Ajouter au panier

Quantité totale7

HVEMContexte de la molécule

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.