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ICOS

ICOS Overview

English NameInducible T-cell costimulatorApproved Drugs0
Drugs in Clinical Trials7Target SynonymActivation-inducible lymphocyte immunomediatory molecule，Inducible T-cell costimulator，ICOS，CD278，AILIM，Inducible T Cell Costimulator，Inducible T-Cell Co-Stimulator，Inducible Costimulator，CD278 Antigen，CVID1，Inducible T-Cell Co-Stimulator Protein
Highest Development StagePhase 2 Clinical
English NameInducible T-cell costimulator
Target SynonymActivation-inducible lymphocyte immunomediatory molecule，Inducible T-cell costimulator，ICOS，CD278，AILIM，Inducible T Cell Costimulator，Inducible T-Cell Co-Stimulator，Inducible Costimulator，CD278 Antigen，CVID1，Inducible T-Cell Co-Stimulator Protein
Approved Drugs0
Drugs in Clinical Trials7
Highest Development StagePhase 2 Clinical

ICOS Product List

  • Product Category

    Protein (6)

  • Product Status

    Launched (6)

  • Species

    Human (3)Mouse (2)Rat (1)

  • Tag

    His Tag & Avi Tag (1)Fc Tag (2)His Tag (3)

  • Conjugate

    Biotin-labeled (1)Unconjugated (5)

Total: 6
  • 1

ICOS Background

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

ICOS Synonyms

ICOS,CD278,AILIM,Inducible T-cell costimulator
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