IFN-gamma Overview
Molecule Name
Interferon gamma
Synonyms
Interferon-gamma ,Interferon-γ
Drug Development Progress
Drugs in Clinical Trials13
Approved Drugs4
Highest Development StageApproved
Target Synonym
Immune interferon，Interferon gamma，IFNG，IFN-Gamma，IFG，IFI，Interferon-gamma
Background
Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.
IFN-gamma Product List
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M***r2025-10-31Reliable and easy-to-use ELISA kit with high sensitivity and consistent results. Standards and controls performed as expected, and the shorter assay time is a great advantage for our studies.