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IGF-II R

IGF-II R Overview

English Name	Insulin-like growth factor II receptor	Approved Drugs	1
Drugs in Clinical Trials	0	Target Synonym	Insulin-like growth factor 2 receptor，IGF-II receptor，CD222，Insulin Like Growth Factor 2 Receptor，M6P/IGF2R，M6P/IGF2 receptor，CI Man-6-P receptor，Insulin-like growth factor II receptor，IGF2R，300 KDa Mannose 6-Phosphate Receptor，MPR 300，MPRI，Cation-Independent Mannose-6-Phosphate Receptor，Cation-Independent Mannose-6 Phosphate Receptor，CD222 Antigen，CI-M6PR，MPR300，CI-MPR，CIMPR，M6P-R，MPR1，M6PR，Receptor， IGF Type 2
Highest Development Stage	Approved

English Name	Insulin-like growth factor II receptor
Target Synonym	Insulin-like growth factor 2 receptor，IGF-II receptor，CD222，Insulin Like Growth Factor 2 Receptor，M6P/IGF2R，M6P/IGF2 receptor，CI Man-6-P receptor，Insulin-like growth factor II receptor，IGF2R，300 KDa Mannose 6-Phosphate Receptor，MPR 300，MPRI，Cation-Independent Mannose-6-Phosphate Receptor，Cation-Independent Mannose-6 Phosphate Receptor，CD222 Antigen，CI-M6PR，MPR300，CI-MPR，CIMPR，M6P-R，MPR1，M6PR，Receptor， IGF Type 2
Approved Drugs	1
Drugs in Clinical Trials	0
Highest Development Stage	Approved

IGF-II R Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
His Tag (2)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
IGR-H52H4	Human	HEK293	Human IGF-II R (43-1365) Protein, His Tag (MALS verified)
IGR-H53H3	Human	CHO	Human IGF-II R Protein, His Tag (MALS verified)

Total: 2

IGF-II R Background

IGF2R, also known as the cation-independent mannose-6-phosphate receptor, is found ubiquitously in human tissues with a truncated soluble form of the receptor present in the circulation. Full-length, 300-kDa, IGF2R comprises a large N-terminal extracellular region of 15 homologous domains, a single membrane-spanning region and a small cytoplasmic tail. In addition to IGF-II binding, major IGF2R functions include sorting newly synthesized lysosomal enzymes and endocytosis of extracellular lysosomal enzymes. To perform these disparate functions, the extracellular region contains binding sites for IGF-II and phosphomannosyl residues

IGF-II R Synonyms

Cation-independent mannose-6-phosphate receptor,CI Man-6-P receptor,CI-MPR,M6PR,300 kDa mannose 6-phosphate receptor (MPR 300),Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor (IGF-II receptor),M6P/IGF2 receptor (M6P/IGF2R),CD2

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Avalglucosidase alfa	neoGAA; GZ-402666; Neo-rhGAA; NeoGAA	Approved	Genzyme Corp	Nexviazyme, Nexviadyme, 耐而赞	United States	Glycogen Storage Disease Type II	Genzyme Corp	2021-08-06	Glycogen Storage Disease Type II	Details