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IGFBP-2

IGFBP-2 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (1)Mouse (1)
Tag
His Tag (1)- (1)
Conjugate
Unconjugated (1)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
IG2-H52H4	Human	HEK293	Human IGFBP-2 Protein, His Tag (MALS verified)
IG2-M82D3	Mouse	HEK293	Biotinylated Mouse IGFBP-2 Protein, His,Avitag™&Flag Tag (MALS verified)

Total: 2

IGFBP-2 Background

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Cenicriviroc mesylate	CCR5/CCR2 antagonist; TBR-652; CVC; TAK-652	Phase 3 Clinical	Tobira Therapeutics Inc, Takeda Pharmaceutical Co Ltd	Prediabetic State; HIV Infections; Acquired Immunodeficiency Syndrome; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Liver Cirrhosis; Coronavirus Disease 2019 (COVID-19); AIDS Dementia Complex; Cholangitis, Sclerosing; Hepatic Insufficiency; Obesity; Cognition Disorders	Details
SB-728-T	SB-728mR-T; SB-728-T	Phase 2 Clinical	Sangamo Biosciences	HIV Infections	Details
Vicriviroc	SCH-D; MK-4176; SCH-417; Sch-417690	Phase 2 Clinical	Merck & Co Inc	HIV Infections; Acquired Immunodeficiency Syndrome; Colorectal Neoplasms	Details
Leronlimab	HuPRO-140; PA-14; PRO-140	Phase 2 Clinical	Cytodyn Inc	HIV Infections; Solid tumours; Metabolic Dysfunction-Associated Steatotic Liver Disease; Rectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Triple Negative Breast Neoplasms; Colorectal Neoplasms	Details
BMS-813160	BMS-813160	Phase 2 Clinical	Bristol-Myers Squibb Company	Pancreatic Neoplasms; Diabetic Nephropathies; Hyperplasia; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung	Details
Cenicriviroc mesylate/Tropifexor	LJC-242	Phase 2 Clinical	Novartis Pharma Ag	Metabolic Dysfunction-Associated Steatotic Liver Disease	Details
AGT 103-T	AGT 103-T	Phase 1 Clinical	American Gene Technologies International Inc	HIV Infections	Details
Thioraviroc		Phase 1 Clinical	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	HIV Infections	Details
BMS-687681	BMS-687681	Phase 1 Clinical	Bristol-Myers Squibb Company	Neoplasms	Details
SB-728-HSC	SB-728-HSC; SB-728-HSPC; SB-728mR-HSPC	Phase 1 Clinical	Sangamo Biosciences	HIV Infections; HIV Seropositivity	Details
LF-0376	LF-0376	Phase 1 Clinical	Wuxi Hillhouse biomedicine Technology Co Ltd	Solid tumours; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Pancreatic Neoplasms; Colorectal Neoplasms; Lymphoma	Details
OB-002	OB-002; OB-002M; OB-002O; OB-002H; OB-002C; 5P12-RANTES; 5P12-RANTES-E66S	Phase 1 Clinical	Mintaka Medical Research Foundation	HIV Infections; Stomach Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Maraviroc	MVC; UK-427857	Approved	Viiv Healthcare	Celsentri, Selzentry	United States	HIV Infections	Viiv Healthcare Co	2007-08-06	HIV Infections; Acquired Immunodeficiency Syndrome; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hypertriglyceridemia; Arthritis, Rheumatoid; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Kidney Diseases; Stroke; AIDS Dementia Complex; Cardiovascular Diseases; Inflammation; HIV Seropositivity; Sarcoma, Kaposi	Details