IL-1 Rrp2

IL-1 Rrp2 Informations sur la molécule

Nom anglais	Interleukin-36 receptor	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	4	Alias de la cible	Interleukin-1 Receptor-Related Protein 2，Interleukin-1 Receptor-Like 2，IL-1Rrp2，Interleukin 1 Receptor Like 2，EC:3.2.2.6，IL-36R，IL1RRP2，IL-36 Receptor，IL1R-Rp2，IL1RL2，IL-1 Receptor-Related Protein 2
Phase de R&D la plus avancée	Approved

Nom anglais	Interleukin-36 receptor
Alias de la cible	Interleukin-1 Receptor-Related Protein 2，Interleukin-1 Receptor-Like 2，IL-1Rrp2，Interleukin 1 Receptor Like 2，EC:3.2.2.6，IL-36R，IL1RRP2，IL-36 Receptor，IL1R-Rp2，IL1RL2，IL-1 Receptor-Related Protein 2
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	4
Phase de R&D la plus avancée	Approved

IL-1 Rrp2 Liste de produits

Attribut
Protein (5)
Bibliothèque de produits
En ligne (5)
Espèces
Human (4)Cynomolgus (1)
Étiquette
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
Marqueur
Unconjugated (4)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT IL2-H5254	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 Protein, Fc Tag	Ajouter au panier
HOT IL2-H52H4	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 (C154S, C262S) Protein, His Tag (MALS verified)	Ajouter au panier
HOT IL2-H52H6	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag, low endotoxin	Ajouter au panier
HOT IL2-H82E9	Human	HEK293	Biotinylated Human IL-1 Rrp2 / IL-1 R6 Protein, His,Avitag™	Ajouter au panier
HOT IL2-C52H5	Cynomolgus	HEK293	Cynomolgus IL-1 Rrp2 / IL-1 R6 Protein, His Tag	Ajouter au panier

Quantité totale5

IL-1 Rrp2Contexte de la molécule

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-1 Rrp2Alias de la molécule

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
HB-0043	HB-0043	Phase 2 Clinical	HuaBo Biopharm Co Ltd	Acne Vulgaris; Arthritis, Rheumatoid; Autoimmune Diseases; Dermatitis, Atopic; Hidradenitis Suppurativa; Lupus Erythematosus, Systemic; Lupus Nephritis; Psoriasis; Renal Insufficiency, Chronic	Details
SHR-1139	SHR1139; SHR-1139	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Colitis, Ulcerative; Plaque psoriasis; Psoriasis; Pyoderma Gangrenosum	Details
TQH-2929	TQH-2929; TQH2929	Phase 2 Clinical	Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group	Generalised pustular psoriasis; Psoriasis; Pustular psoriasis	Details
IMG-008	IMG008	Phase 1 Clinical	Ikena Oncology Inc	Autoimmune Diseases; Inflammation	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Spesolimab	BI-655130	Approved	C.H. Boehringer Sohn Ag & Co. Kg	圣利卓, Spevigo	United States	Psoriasis	Boehringer Ingelheim Pharmaceuticals Inc	2022-09-01	Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Generalised pustular psoriasis; Hidradenitis Suppurativa; Netherton Syndrome; Palmoplantar pustulosis; Psoriasis; Pyoderma Gangrenosum	Details