IL-12A

IL-12A Informations sur la molécule

Nom anglais	Interleukin-12 subunit alpha	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0	Alias de la cible	IL-12A，Cytotoxic lymphocyte maturation factor 35 kDa subunit，CLMF p35，IL-12 subunit p35，NK cell stimulatory factor chain 1，NKSF1
Phase de R&D la plus avancée	Discontinued

Nom anglais	Interleukin-12 subunit alpha
Alias de la cible	IL-12A，Cytotoxic lymphocyte maturation factor 35 kDa subunit，CLMF p35，IL-12 subunit p35，NK cell stimulatory factor chain 1，NKSF1
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0
Phase de R&D la plus avancée	Discontinued

IL-12A Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
Fc Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
NK1-H5252	Human	HEK293	Human IL-12A / NKSF1 / p35 Protein, Fc Tag				Ajouter au panier

Quantité totale1

IL-12AContexte de la molécule

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.