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IL-17 RA

IL-17 RA Overview

English Name	Interleukin-17 receptor A	Approved Drugs	1
Drugs in Clinical Trials	2	Target Synonym	CDw217，IL-17 receptor A，IL17R，IL17RA，Interleukin 17 Receptor A，IL-17RA，Interleukin 17 Receptor，CD217 Antigen，HIL-17R，CANDF5，CD217，IMD51，Interleukin-17 receptor A
Highest Development Stage	Approved

English Name	Interleukin-17 receptor A
Target Synonym	CDw217，IL-17 receptor A，IL17R，IL17RA，Interleukin 17 Receptor A，IL-17RA，Interleukin 17 Receptor，CD217 Antigen，HIL-17R，CANDF5，CD217，IMD51，Interleukin-17 receptor A
Approved Drugs	1
Drugs in Clinical Trials	2
Highest Development Stage	Approved

IL-17 RA Product List

Product Category
Protein (7)
Product Status
Launched (7)
Species
Human (4)Cynomolgus (1)Rat (1)Mouse (1)
Tag
His Tag (3)Fc Tag & Avi Tag (1)His Tag & Avi Tag (1)Fc Tag (2)
Conjugate
Unconjugated (5)Biotin-labeled (2)

Cat. No.	Species	Host	Product Description
HOT ILA-H82F1	Human	HEK293	Biotinylated Human IL-17 RA / CD217 Protein, Fc,Avitag™
ILA-H5222	Human	HEK293	Human IL-17 RA / CD217 Protein, His Tag
ILA-H525f	Human	HEK293	Human IL-17 RA / CD217 Protein, Fc Tag (MALS verified)
ILR-H82E5	Human	HEK293	Biotinylated Human IL-17 RA / CD217 Protein, His,Avitag™
ILA-M52H6	Mouse	HEK293	Mouse IL-17 RA / CD217 Protein, His Tag (MALS verified)
ILA-C52H9	Cynomolgus	HEK293	Cynomolgus IL-17 RA / CD217 Protein, His Tag (MALS verified)
ILA-R5253	Rat	HEK293	Rat IL-17 RA / CD217 Protein, Fc Tag (MALS verified)

Total: 7

IL-17 RA Background

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

IL-17 RA Synonyms

CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
XCUR-17	XCUR-17	Phase 1 Clinical	Exicure Inc	Psoriasis	Details
PN-881	PN-881	Phase 1 Clinical	Protagonist Therapeutics Inc	Dermatitis; Psoriasis	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Brodalumab	AMG-827; KHK-4827; IL-17R mAb; MEDI-6365	Approved	Amgen Inc	Siliq, Lumicef, Kyntheum, 立美芙	Japan	Psoriasis; Arthritis, Psoriatic	Kyowa Kirin Co Ltd	2016-07-04	Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Axial Spondyloarthritis; Brain Neoplasms; Breast Neoplasms; Colonic Neoplasms; Crohn Disease; Esophageal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Hidradenitis Suppurativa; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Mouth Neoplasms; Non-radiographic axial spondyloarthritis; Palmoplantar pustulosis; Pancreatic Neoplasms; Plaque psoriasis; Prostatic Neoplasms; Psoriasis; Pustular psoriasis; Rectal Neoplasms; Scleroderma, Systemic; Skin Neoplasms; Solid tumours; Spondylitis, Ankylosing; Stomach Neoplasms; Testicular Neoplasms; Thyroid Neoplasms	Details