IL-17B Informations sur la molécule
Molecule Name
Interleukin-17 receptor B
Alias de la molécule
Interleukin-17B,Cytokine Zcyto7,Interleukin-20,IL-20,Neuronal interleukin-17-related factor,IL17B,IL20, NIRF, ZCYTO7
Drug Development Progress
Nombre de médicaments cliniques1
Nombre de médicaments commercialisés0
Phase de R&D la plus avancéePhase 2 Clinical
Alias de la cible
IL-17 receptor B，IL-17RB，Cytokine receptor-like 4，IL-17 receptor homolog 1，IL-17Rh1，IL17Rh1，Interleukin-17B receptor，IL-17B receptor
Contexte de la molécule
IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.
IL-17B Liste de produits
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Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| SM-17 | SM-17; SM17 | Phase 2 Clinical | Sinomab Bioscience Ltd | Asthma; Dermatitis, Atopic; Idiopathic Pulmonary Fibrosis; Inflammatory Bowel Diseases | Details |