IL-24

English

IL-24 Informations sur la molécule

Molecule Name

Interleukin 24

Alias de la molécule

Interleukin-24,IL-24,Melanoma differentiation-associated gene 7 protein,MDA-7,Suppression of tumorigenicity 16 protein,IL24,MDA7,ST16

Drug Development Progress

Nombre de médicaments cliniques1

Nombre de médicaments commercialisés0

Phase de R&D la plus avancéePhase 1 Clinical

Alias de la cible

ST16，Interleukin-24，IL24，MDA-7，Suppression of tumorigenicity 16 protein，IL-24，Interleukin 24，Suppression Of Tumorigenicity 16 (Melanoma Differentiation)，Melanoma Differentiation-Associated Gene 7 Protein，IL-4-Induced Secreted Protein，MDA7，Melanoma Differentiation Association Protein 7，Melanocyte-Associated Mda-7，IL10B，C49A，FISP，MOB5，Mob-5

Contexte de la molécule

Interleukin-24 (IL-24, also known as melanoma differentiation-associated gene-7) belongs to the family of IL-10-related cytokines, which includes IL-10, -19, -20, -22, -24 and -26. Interleukin 24 signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. Upon binding to its receptors, IL-24 induces rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation . Structurally and functionally, IL-24 is highly conserved across species.IL-24 has been shown to possess cancer-specific apoptosis-inducing activity, and has therefore been suggested as a potential anti-cancer agent.