IL-36 gamma

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IL-36 gamma Informations sur la molécule

Molecule Name

Interleukin-36 gamma

Alias de la molécule

IL36G,IL-1RP2,IL-1 epsilon,IL-1F9,IL-1H1,IL1E,IL1F9,IL1H1,IL1RP2

Drug Development Progress

Nombre de médicaments cliniques1

Nombre de médicaments commercialisés0

Phase de R&D la plus avancéePhase 1 Clinical

Alias de la cible

IL-1-related protein 2，IL-1RP2，Interleukin-1 epsilon，IL-1 epsilon，Interleukin-1 family member 9，IL-1F9，Interleukin-1 homolog 1，IL-1H1，IL1E，IL1F9，IL1H1，IL1RP2，Interleukin-1 Homolog 1，Interleukin-1 Epsilon

Contexte de la molécule

Interleukin-36 gamma [previously called IL-1F9, IL-1 epsilon (epsilon), and IL-1H1] is a member of the IL-1 family which includes IL‑1 beta, IL‑1 alpha, IL‑1ra, IL‑18, IL‑36 Ra (IL‑1F5), IL-36 alpha (IL‑1F6), IL‑36 beta (IL‑1F8), IL‑37 (IL‑1F7) and IL-1F10. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.