IL-8

IL-8 Informations sur la molécule

Nom anglais	Interleukin-8	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	6	Alias de la cible	IL8/NAP1 form VI，T-cell chemotactic factor，GCP/IL-8 protein III，IL8/NAP1 form II，GCP/IL-8 protein II，(Ala-IL-8)77，Emoctakin，IL8/NAP1 form IV，LYNAP，IL8/NAP1 form III，IL8/NAP1 form V，GCP/IL-8 protein I，Neutrophil-Activating Peptide 1，Interleukin 8，GCP-1，MDNCF，NAP-1，IL8，Beta Endothelial Cell-Derived Neutrophil Activating Peptide，Lung Giant Cell Carcinoma-Derived Chemotactic Protein，Lymphocyte Derived Neutrophil Activating Peptide，Alveolar Macrophage Chemotactic Factor I，Tumor Necrosis Factor-Induced Gene 1，Small Inducible Cytokine Subfamily B， Member 8，Beta-Thromboglobulin-Like Protein，GCP1，LECT，LUCT，NAP1，IL-8，Interleukin-8，AMCF-I，SCYB8，Neutrophil-Activating Protein 1，B-ENAP，3-10C，K60，TSG-1，C-X-C Motif Chemokine Ligand 8，Monocyte-Derived Neutrophil Chemotactic Factor，Monocyte-Derived Neutrophil-Activating Peptide，Granulocyte Chemotactic Protein 1，Chemokine (C-X-C Motif) Ligand 8，(Ser-IL-8)72，Neutrophil-activating factor，MDNCF-c，C-X-C motif chemokine 8，Lymphocyte-derived neutrophil-activating factor，Protein 3-10C，IL-8(1-77)，NAF，GCP/IL-8 protein VI，GCP/IL-8 protein IV，IL8/NAP1 form I，MONAP，MDNCF-b，GCP/IL-8 protein V，CXCL8
Phase de R&D la plus avancée	Approved

Nom anglais	Interleukin-8
Alias de la cible	IL8/NAP1 form VI，T-cell chemotactic factor，GCP/IL-8 protein III，IL8/NAP1 form II，GCP/IL-8 protein II，(Ala-IL-8)77，Emoctakin，IL8/NAP1 form IV，LYNAP，IL8/NAP1 form III，IL8/NAP1 form V，GCP/IL-8 protein I，Neutrophil-Activating Peptide 1，Interleukin 8，GCP-1，MDNCF，NAP-1，IL8，Beta Endothelial Cell-Derived Neutrophil Activating Peptide，Lung Giant Cell Carcinoma-Derived Chemotactic Protein，Lymphocyte Derived Neutrophil Activating Peptide，Alveolar Macrophage Chemotactic Factor I，Tumor Necrosis Factor-Induced Gene 1，Small Inducible Cytokine Subfamily B， Member 8，Beta-Thromboglobulin-Like Protein，GCP1，LECT，LUCT，NAP1，IL-8，Interleukin-8，AMCF-I，SCYB8，Neutrophil-Activating Protein 1，B-ENAP，3-10C，K60，TSG-1，C-X-C Motif Chemokine Ligand 8，Monocyte-Derived Neutrophil Chemotactic Factor，Monocyte-Derived Neutrophil-Activating Peptide，Granulocyte Chemotactic Protein 1，Chemokine (C-X-C Motif) Ligand 8，(Ser-IL-8)72，Neutrophil-activating factor，MDNCF-c，C-X-C motif chemokine 8，Lymphocyte-derived neutrophil-activating factor，Protein 3-10C，IL-8(1-77)，NAF，GCP/IL-8 protein VI，GCP/IL-8 protein IV，IL8/NAP1 form I，MONAP，MDNCF-b，GCP/IL-8 protein V，CXCL8
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	6
Phase de R&D la plus avancée	Approved

IL-8 Liste de produits

Attribut
Protein (5)Kits (2)
Bibliothèque de produits
En ligne (7)
Espèces
Human (6)Rhesus macaque (1)
Étiquette
His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)- (2)Tag Free (1)
Marqueur
Unconjugated (4)Biotin-labeled (1)- (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT CRS-B004	Human	-	Human IL-8 ELISA Kit	Ajouter au panier
HOT IL8-H5217	Human	HEK293	Human IL-8 / CXCL8 Protein, premium grade	Ajouter au panier
HOT IL8-H52H3	Human	HEK293	Human IL-8 / CXCL8 Protein, His Tag	Ajouter au panier
HOT IL8-H82H3	Human	HEK293	Biotinylated Human IL-8 protein, His,Avitag™	Ajouter au panier
HOT IL8-C52H4	Rhesus macaque	HEK293	Rhesus macaque IL-8 / CXCL8 Protein, His Tag (MALS verified)	Ajouter au panier
CEA-C004	Human	-	Human IL-8 ELISA Kit, PRO	Ajouter au panier
IL8-H5258	Human	HEK293	Human IL-8 / CXCL8 Protein, Fc Tag	Ajouter au panier

Quantité totale7

Demande de produit

IL-8Contexte de la molécule

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

IL-8Alias de la molécule

CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Ensereptide	PXL-01	Phase 3 Clinical	Promore Pharma	Cicatrix; Post-surgical adhesions; Tissue Adhesions	Details
Cinainu		Phase 3 Clinical	Legacy Healthcare (Switzerland) Sa	Alopecia Areata	Details
Sodium Hypochlorite		Phase 3 Clinical		Cystic Fibrosis; Dental Pulp Necrosis; Fibrosis; Infections; Pain; Pain, Postoperative; Pulpitis	Details
Adakitug	BMS-986253; MDX-018	Phase 2 Clinical	Bristol-Myers Squibb Company, Genmab A/S, Medarex Inc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Coronavirus Disease 2019 (COVID-19); Hematologic Neoplasms; Melanoma; Myelodysplastic Syndromes; Neoplasms; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
AMY-109	AMY-109; AMY109	Phase 2 Clinical	Chugai Pharmaceutical Co Ltd	Endometriosis; Solid tumours	Details
AC-701	AC-701	Phase 2 Clinical	Twi Pharmaceuticals Inc	Exanthema; Rosacea	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Mouse monoclonal antibody against human interleukin-8 cream		Approved	Dalian Asia Space Pharmaceutical Co Ltd, Dongguan Hongyuan Yishi Biotechnology Pharmaceutical Co Ltd	恩博克	Mainland China	Eczema; Psoriasis	Dalian Asia Space Pharmaceutical Co Ltd	2001-04-10	Eczema; Psoriasis	Details