ILDR2

ILDR2 Informations sur la molécule

Nom anglais	Immunoglobulin-like domain-containing receptor 2	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	Immunoglobulin-like domain-containing receptor 2
Alias de la cible	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 1 Clinical

ILDR2 Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
Fc Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
IL2-H5259	Human	HEK293	Human ILDR2 Protein, Fc Tag				Ajouter au panier

Quantité totale1

ILDR2Contexte de la molécule

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.