Integrin alpha D beta 2

Integrin alpha D beta 2 Informations sur la molécule

Nom anglais	Integrin alpha-4	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3	Alias de la cible	CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Integrin alpha-4
Alias de la cible	CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Phase 2 Clinical

Integrin alpha D beta 2 Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
IT2-H53W6	Human	CHO	Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free				Ajouter au panier

Quantité totale1

Integrin alpha D beta 2Contexte de la molécule

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.

Integrin alpha D beta 2Alias de la molécule

Integrin alpha D beta 2,ITGAD & ITGB2

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Avicursen	TV-1102; ATL/TV-1102; ATL-1102; ISIS-107248	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Multiple Sclerosis; Muscular Dystrophy, Duchenne	Details
BIIB-107 (Biogen)	BIIB-107	Phase 1 Clinical	Biogen Inc	Multiple Sclerosis	Details
ELND-004	ELND-004	Phase 1 Clinical	Perrigo Company Plc	Autoimmune Diseases	Details