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Page d'accueilToutes les moléculesIntegrin alpha L beta 2
Integrin alpha L beta 2
Integrin alpha L beta 2 Informations sur la molécule
| Nom anglais | Integrin alpha-L/beta-2 (LFA-1) | Nombre de médicaments commercialisés | 1 |
| Nombre de médicaments cliniques | 1 | Alias de la cible | Lymphocyte Function-Associated Antigen-1 |
| Phase de R&D la plus avancée | Approved | ||
| Nom anglais | Integrin alpha-L/beta-2 (LFA-1) |
| Alias de la cible | Lymphocyte Function-Associated Antigen-1 |
| Nombre de médicaments commercialisés | 1 |
| Nombre de médicaments cliniques | 1 |
| Phase de R&D la plus avancée | Approved |
Integrin alpha L beta 2 Liste de produits
- Attribut
Protein (1)
- Bibliothèque de produits
En ligne (1)
- Espèces
Human (1)
- Étiquette
His Tag (1)
- Marqueur
Unconjugated (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
IT2-H53W3 |  Human | CHO | Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free |  |  |  |  Ajouter au panier |
Quantité totale1
- 1
Integrin alpha L beta 2Contexte de la molécule
Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Integrin alpha L beta 2Alias de la molécule
Integrin alpha L beta 2,ITGAL&ITGB2
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Alintegimod | 7HP349; 7-HP-349; 7HP-349 | Phase 2 Clinical | 7 Hills Pharma LLC | Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Chagas Disease; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Influenza, Human; Kidney Neoplasms; Lymphoma; Melanoma; Mesothelioma; Mismatch Repair Deficient Cancer; Neoplasm Metastasis; Neoplasms; Skin Neoplasms; Solid tumours; Tuberculosis | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Lifitegrast | SHP-606; SAR-1119; SAR-1118; SPD-606; OJL-332 | Approved | Shire Development Llc | Xiidra, 朗悦明 | United States | Dry Eye Syndromes | Bausch And Lomb Inc | 2016-07-11 | Conjunctivitis, Allergic; Diabetic macular oedema; Dry Eye Syndromes; Graft vs Host Disease; Keratoconjunctivitis Sicca; Xerophthalmia | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments commercialisés
- Informations sur les médicaments cliniques
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