KLRG1

KLRG1 Informations sur la molécule

Nom anglais	Killer cell lectin-like receptor subfamily G member 1	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
Phase de R&D la plus avancée	Phase 3 Clinical

Nom anglais	Killer cell lectin-like receptor subfamily G member 1
Alias de la cible	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 3 Clinical

KLRG1 Liste de produits

Attribut
Protein (5)
Bibliothèque de produits
En ligne (5)
Espèces
Human (1)Mouse (1)Cynomolgus (3)
Étiquette
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
Marqueur
Unconjugated (4)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT KL1-H5249	Human	HEK293	Human KLRG1 Protein, His Tag	Ajouter au panier
HOT KL1-M5249	Mouse	HEK293	Mouse KLRG1 Protein, His Tag (MALS & SPR verified)	Ajouter au panier
HOT KL1-C5243	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, His Tag (SPR verified)	Ajouter au panier
HOT KL1-C5269	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, Fc Tag (SPR verified)	Ajouter au panier
KL1-C82Q4	Cynomolgus	HEK293	Biotinylated Cynomolgus KLRG1 Protein, Avitag™,His Tag	Ajouter au panier

Quantité totale5

KLRG1Contexte de la molécule

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.