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KLRG1

KLRG1 Overview

English Name	Killer cell lectin-like receptor subfamily G member 1	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
Highest Development Stage	Phase 3 Clinical

English Name	Killer cell lectin-like receptor subfamily G member 1
Target Synonym	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 3 Clinical

KLRG1 Product List

Product Category
Protein (5)
Product Status
Launched (5)
Species
Human (1)Mouse (1)Cynomolgus (3)
Tag
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT KL1-H5249	Human	HEK293	Human KLRG1 Protein, His Tag
HOT KL1-M5249	Mouse	HEK293	Mouse KLRG1 Protein, His Tag (MALS & SPR verified)
HOT KL1-C5243	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, His Tag (SPR verified)
HOT KL1-C5269	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, Fc Tag (SPR verified)
KL1-C82Q4	Cynomolgus	HEK293	Biotinylated Cynomolgus KLRG1 Protein, Avitag™,His Tag

Total: 5

KLRG1 Background

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.