LGR5

LGR5 Informations sur la molécule

Nom anglais	Leucine-rich repeat-containing G-protein coupled receptor 5	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2	Alias de la cible	FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Leucine-rich repeat-containing G-protein coupled receptor 5
Alias de la cible	FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2
Phase de R&D la plus avancée	Phase 2 Clinical

LGR5 Liste de produits

Attribut
Protein (4)Cell (1)
Bibliothèque de produits
En ligne (5)
Espèces
Human (4)Cynomolgus (1)
Étiquette
His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)- (1)
Marqueur
Unconjugated (3)Biotin-labeled (1)- (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
CHEK-ATP327	Human	HEK293	HEK293/Human LGR5 Stable Cell Line	Ajouter au panier
LG5-H5253	Human	HEK293	Human LGR5 / GPR49 protein, Fc Tag	Ajouter au panier
LG5-H52H3	Human	HEK293	Human LGR5 / GPR49 Protein, His Tag, low endotoxin	Ajouter au panier
LG5-H82E4	Human	HEK293	Biotinylated Human LGR5 / GPR49 (22-561) Protein, His,Avitag™	Ajouter au panier
LG5-C52H7	Cynomolgus	HEK293	Cynomolgus LGR5 / GPR49 protein, His Tag	Ajouter au panier

Quantité totale5

LGR5Contexte de la molécule

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5Alias de la molécule

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Petosemtamab	MCLA-158	Phase 2 Clinical	Merus Nv	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	Details
CNA-3103	CNA-3103	Phase 2 Clinical	Carina Biotech Pty Ltd	Colorectal Neoplasms	Details