LIF

LIF Informations sur la molécule

Nom anglais	Leukemia inhibitory factor	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2	Alias de la cible	LIF Interleukin 6 Family Cytokine，D factor，Emfilermin，LIF，Differentiation-stimulating factor，LIF， Interleukin 6 Family Cytokine，Differentiation Inhibitory Activity，Cholinergic Differentiation Factor，Hepatocyte-Stimulating Factor III，Differentiation-Inducing Factor，Melanoma-Derived LPL Inhibitor，Human Interleukin In DA Cells，Leukemia Inhibitory Factor，HILDA，MLPLI，CDF，DIA
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Leukemia inhibitory factor
Alias de la cible	LIF Interleukin 6 Family Cytokine，D factor，Emfilermin，LIF，Differentiation-stimulating factor，LIF， Interleukin 6 Family Cytokine，Differentiation Inhibitory Activity，Cholinergic Differentiation Factor，Hepatocyte-Stimulating Factor III，Differentiation-Inducing Factor，Melanoma-Derived LPL Inhibitor，Human Interleukin In DA Cells，Leukemia Inhibitory Factor，HILDA，MLPLI，CDF，DIA
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2
Phase de R&D la plus avancée	Phase 2 Clinical

LIF Liste de produits

Attribut
Protein (6)
Bibliothèque de produits
En ligne (6)
Espèces
Human (4)Mouse (2)
Étiquette
Tag Free (3)His Tag (2)His Tag & Avi Tag (1)
Marqueur
Unconjugated (5)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT LIF-H521b	Human	HEK293	Human LIF Protein, Tag Free	Ajouter au panier
HOT LIF-H52H3	Human	HEK293	Human LIF Protein, His Tag (MALS verified)	Ajouter au panier
HOT LIF-H82E2	Human	HEK293	Biotinylated Human LIF Protein, His,Avitag™	Ajouter au panier
LIF-H5215	Human	HEK293	Human LIF Protein, premium grade	Ajouter au panier
LIF-M5219	Mouse	HEK293	Mouse LIF Protein, Tag Free (MALS verified)	Ajouter au panier
LIF-M5227	Mouse	HEK293	Mouse LIF Protein, His Tag (MALS verified)	Ajouter au panier

Quantité totale6

LIFContexte de la molécule

Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

LIFAlias de la molécule

LIF,CDF,DIA,HILDA,MLPLI

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Falbikitug	AZD-0171; MSC-1	Phase 2 Clinical	Astrazeneca Plc	Carcinoma, Non-Small-Cell Lung; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours	Details
JAB-BX300	JAB-BX300	Phase 2 Clinical	Jacobio Pharmaceuticals Co Ltd	Pancreatic Neoplasms; Solid tumours	Details