LIGHT

LIGHT Informations sur la molécule

Nom anglais	Tumor necrosis factor superfamily member 14	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Tumor necrosis factor superfamily member 14
Alias de la cible	CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

LIGHT Liste de produits

Attribut
Protein (6)Cell (1)
Bibliothèque de produits
En ligne (7)
Espèces
Human (5)Cynomolgus (1)Mouse (1)
Étiquette
Mouse IgG Fc Tag (1)His Tag (4)Fc Tag (1)- (1)
Marqueur
Unconjugated (6)- (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT LIT-H5242	Human	HEK293	Human LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)	Ajouter au panier
HOT LIT-H5269	Human	HEK293	Human LIGHT / TNFSF14 Protein, Fc Tag, active trimer, low endotoxin (MALS verified)	Ajouter au panier
HOT LIT-M5243	Mouse	HEK293	Mouse LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)	Ajouter au panier
HOT LIT-C5244	Cynomolgus	HEK293	Cynomolgus LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)	Ajouter au panier
LIT-H5243	Human	HEK293	Human LIGHT / TNFSF14 Protein, His Tag, Ultra Low Endotoxin (MALS verified)	Ajouter au panier
LIT-H5256	Human	HEK293	Human LIGHT / TNFSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin	Ajouter au panier
SCCHO-ATP109	Human	CHO	CHO/Human LIGHT Stable Cell Line	Ajouter au panier

Quantité totale7

LIGHTContexte de la molécule

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

LIGHTAlias de la molécule

CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Quisovalimab	CERC-002; AEVI-002; MDGN-002; SAR-252067; AVTX-002	Phase 2 Clinical	Kyowa Hakko Kirin Co Ltd, La Jolla Pharmaceutical Company	Acute Lung Injury; Asthma; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Respiratory Distress Syndrome, Adult	Details

Avis sur les produits

E***a2021-09-23
1Mettre un like
Human LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)
We use this protein as an ELISA standard. We are interested in quantifying soluble LIGHT concentration from human serum. This active form of the protein perfectly binds its receptors and policlonal antibodies. The standard curve obtained is highly reproducible. It was very easy to find all the information in the web of AcroBiosystems and to download the CoA, which was also very descriptive.