LOXL2

LOXL2 Informations sur la molécule

Nom anglais	Lysyl oxidase homolog 2	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	EC:1.4.3.13，EC 1.4.3，Lysyl oxidase-like protein 2，Lysyl oxidase homolog 2，LOXL2，Lysyl Oxidase Like 2，Lysyl Oxidase-Related Protein WS9-14，Lysyl Oxidase-Related Protein 2，Lysyl Oxidase-Like 2 Delta E13，Lysyl Oxidase-Like 2 Protein，Lysyl Oxidase Related 2，Lysyl Oxidase-Like 2，EC 1.4.3.13，WS9-14，LOR2，LOR
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Lysyl oxidase homolog 2
Alias de la cible	EC:1.4.3.13，EC 1.4.3，Lysyl oxidase-like protein 2，Lysyl oxidase homolog 2，LOXL2，Lysyl Oxidase Like 2，Lysyl Oxidase-Related Protein WS9-14，Lysyl Oxidase-Related Protein 2，Lysyl Oxidase-Like 2 Delta E13，Lysyl Oxidase-Like 2 Protein，Lysyl Oxidase Related 2，Lysyl Oxidase-Like 2，EC 1.4.3.13，WS9-14，LOR2，LOR
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

LOXL2 Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (2)
Étiquette
His Tag & Avi Tag (1)His Tag (1)
Marqueur
Biotin-labeled (1)Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
LO2-H52H3	Human	HEK293	Human LOXL2 Protein, His Tag (active enzyme)				Ajouter au panier
LO2-H82E3	Human	HEK293	Biotinylated Human LOXL2 Protein, His,Avitag™ (active enzyme)				Ajouter au panier

Quantité totale2

LOXL2Contexte de la molécule

Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.